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專家人才

  • 姓名：郭琳
  • 性別：女
  • 職稱：副研究員
  • 學曆：博士
  • 電話：020-32015291
  • 傳真：
  • 電子郵件:guo_lin09@gibh.ac.cn
  • 通訊地址廣州市科學城開源大道190號

    研究領域：

  • 1.多能性建立與維持的分子機製

    2. 利用單細胞測序技術研究細胞命運決定

    承擔科研項目情況：

    社會任職：

    獲獎及榮譽：

    代表論著：

  • 1.Chen, J.*,Guo, L.*, Zhang, L.*, Wu, H., Yang, J., Liu, H., Wang, X., Hu, X., Gu, T., Zhou, Z., Liu, J., Liu, J., Wu, H., Mao, S.Q., Mo, K., Li, Y., Lai, K., Qi, J., Yao, H., Pan, G., Xu, G.L., and Pei, D. Vitamin C modulates TET1 function during somatic cell reprogramming. Nat Genet, 2013. 45(12): 1504-1509. (*共同第一作者)

    2.Chen, Y.*,Guo, L.*, Chen, J.*, Zhao, X., Zhou, W., Zhang, C., Wang, J., Jin, L., Pei, D., and Zhang, F. Genome-wide CNV analysis in mouse induced pluripotent stem cells reveals dosage effect of pluripotent factors on genome integrity. BMC Genomics, 2014. 1579.

    3.郭琳，陳捷凱，裴端卿，維生素C與表觀遺傳調控，科學通報，2014, 59 (28) :2833-2839

    4.Li, D.*, Liu, J.*, Yang, X.*, Zhou, C., Guo, J., Wu, C., Qin, Y.,Guo, L., He, J., Yu, S., Liu, H., Wang, X., Wu, F., Kuang, J., Hutchins, A.P., Chen, J., and Pei, D. Chromatin Accessibility Dynamics during iPSC Reprogramming. Cell Stem Cell, 2017. 21(6): 819-833 e816.

    5.Chen, J.*, Liu, H.*, Liu, J., Qi, J., Wei, B., Yang, J., Liang, H., Chen, Y., Chen, J., Wu, Y.,Guo, L., Zhu, J., Zhao, X., Peng, T., Zhang, Y., Chen, S., Li, X., Li, D., Wang, T., and Pei, D. H3K9 methylation is a barrier during somatic cell reprogramming into iPSCs. Nat Genet, 2013. 45(1): 34-42.

    6.Chen, J.*, Liu, J.*, Chen, Y., Yang, J., Chen, J., Liu, H., Zhao, X., Mo, K., Song, H.,Guo, L., Chu, S., Wang, D., Ding, K., and Pei, D. Rational optimization of reprogramming culture conditions for the generation of induced pluripotent stem cells with ultra-high efficiency and fast kinetics. Cell Res, 2011. 21(6): 884-894.

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