| Design, Synthesis, and Structure-Activity Relationship Study of 2-Oxo-3,4-dihydropyrimido[4,5- d]pyrimidines as New Colony Stimulating Factor 1 Receptor (CSF1R) Kinase Inhibitors |
Qiuju Xun,Zhang Zhang,Jinfeng Luo,Linjiang Tong,Minhao Huang, Zhen Wang,Jian Zou, Yingqiang Liu,Yong Xu, Hua Xie,Zheng-Chao Tu, Xiaoyun Lu,Ke Ding |
2018 Mar; |
Journal of Medicinal Chemistry |
| Benzoxazinone-containing 3,5-dimethylisoxazole derivatives as BET bromodomain inhibitors for treatment of castration-resistant prostate cancer |
Xiaoqian Xue,Yan Zhang,Chao Wang,Maofeng Zhang,Qiuping Xiang,Junjian Wang,Anhui Wang, Chenchang Li,Cheng Zhang,Lingjiao Zou,Rui Wang,Shuang Wu,Yongzhi Lu,Hongwu Chen,Ke Ding, Guohui Li,Yong Xu |
2018 May; |
European Journal of Medicinal Chemistry |
| Discovery and optimization of 1-(1H-indol-1-yl)ethanone derivatives as CBP/EP300 bromodomain inhibitors for the treatment of castration-resistant prostate cancer |
Qiuping Xiang,Chao Wang,Yan Zhang, Xiaoqian Xue, Ming Song,Cheng Zhang, Chenchang Li, Chun Wu,Kuai Li,Xiaoyan Hui,Yulai Zhou,Jeff B. Smaill,Adam V. Patterson,Donghai Wu,Ke Ding,Yong Xu |
2018 Mar; |
European Journal of Medicinal Chemistry |
| Structure-Based Discovery and Optimization of Benzo[d]isoxazole Derivatives as Potent and Selective BET Inhibitors for Potential Treatment of Castration-Resistant Prostate Cancer (CRPC).Journal of Medicinal Chemistry |
Maofeng Zhang, Yan Zhang, Ming Song, Xiaoqian Xue, Junjian Wang, Chao Wang, Cheng Zhang, Chenchang Li, Qiuping Xiang, Lingjiao Zou, Xishan Wu, Chun Wu, Baijun Dong, Wei Xue, Yulai Zhou, Hongwu Chen, Donghai Wu, Ke Ding,Yong Xu |
2018 Apr; |
Journal of Medicinal Chemistry |
| PCGF5 is required for neural differentiation of embryonic stem cells |
Mingze Yao, Xueke Zhou, Jiajian Zhou, Shixin Gong, Gongcheng Hu, Jiao Li,Kaimeng Huang, Ping Lai, Guang Shi, Andrew P. Hutchins, Hao Sun,Huating Wang,Hongjie Yao |
2018 May; |
Nature Communications |
| Pd-Catalyzed Divergent C(sp2)-H Activation/Cycloimidoylation of 2-Isocyano-2,3-diarylpropanoates |
Shi Tang, Sheng-Wen Yang, Hongwei Sun, Yali Zhou, Juan Li,Qiang Zhu |
2018 Apr; |
Organic Letters |
| Enantioselective Synthesis of Planar Chiral Pyridoferrocenes via Palladium-Catalyzed Imidoylative Cyclization Reactions |
Shuang Luo,Zhuang Xiong,Yongzhi Lu,Qiang Zhu |
2018 Apr; |
Organic Letters |
| Chromatin Accessibility Dynamics during Chemical Induction of Pluripotency |
Shangtao Cao, Shengyong Yu, Dongwei Li, Jing Ye, Xuejie Yang, Chen Li, Xiaoshan Wang, Yuanbang Mai, Yue Qin, Jian Wu, Jiangping He, Chunhua Zhou, He Liu, Bentian Zhao, Xiaodong Shu, Chuman Wu, Ruiping Chen, Waiyee Chan, Guangjin Pan, Jiekai Chen, Jing Liu, Duanqing Pei |
2018 Apr; |
Cell Stem Cell |
| A Huntingtin Knockin Pig Model Recapitulates Features of Selective Neurodegeneration in Huntington's Disease |
Sen Yan, Zhuchi Tu, Zhaoming Liu, Nana Fan, Huiming Yang, Su Yang, Weili Yang, Yu Zhao, Zhen Ouyang, Chengdan Lai, Huaqiang Yang, Li Li, Qishuai Liu, Hui Shi, Guangqing Xu, Heng Zhao, Hongjiang Wei, Zhong Pei, Shihua Li, Liangxue Lai, Xiao-Jiang Li |
2018 May; |
Cell |
| NCoR/SMRT co-repressors cooperate with c-MYC to create an epigenetic barrier to somatic cell reprogramming |
Qiang Zhuang, Wenjuan Li, Christina Benda, Zhijian Huang, Tanveer Ahmed, Ping Liu, Xiangpeng Guo, David P. Iba？ez, Zhiwei Luo, Meng Zhang, Mazid Md. Abdul, Zhongzhou Yang, Jiayin Yang, Yinghua Huang, Hui Zhang, Dehao Huang, Jianguo Zhou, Xiaofen Zhong, Xihua Zhu, Xiuling Fu, Wenxia Fan, Yulin Liu, Yan Xu, Carl Ward, Muhammad Jadoon Khan, Shahzina Kanwal, Bushra Mirza, Micky D. Tortorella, Hung-Fat Tse, Jiayu Chen, Baoming Qin, Xichen Bao, Shaorong Gao, Andrew P. Hutchins ,Miguel A. Esteban |
2018 Apr; |
Nature Cell Biology |
| A divergent and concise total synthesis of (-)-lycoposerramine R and (+)-lycopladine A |
Sheng Chen,Jinming Wang,Fayang G.Qiu |
2018 Apr; |
Chemical Communications |
| Proteome-wide identification of ubiquitin interactions using UbIA-MS |
Xiaofei Zhang,Arne H Smits,Gabrielle BA van Tilburg,Huib Ovaa,Wolfgang Huber,Michiel Vermeulen |
2018 Mar; |
Nature Protocols |
| Transcription factor Hoxb5 reprograms B cells into functional T lymphocytes |
Mengyun Zhang, Yong Dong, Fangxiao Hu, Dan Yang, Qianhao Zhao, Cui Lv, Ying Wang, Chengxiang Xia, Qitong Weng, Xiaofei Liu, Chen Li, Peiqing Zhou, Tongjie Wang, Yuxian Guan, Rongqun Guo, Lijuan Liu, Yang Geng, Hongling Wu, Juan Du, Zheng Hu, Sheng Xu, Jiekai Chen, Aibin He, Bing Liu, Demin Wang, Yong-Guang Yang,Jinyong Wang |
2018 Mar; |
Nature Immunology |
| Capturing the interactome of newly transcribed RNA |
Xichen Bao, Xiangpeng Guo, Menghui Yin, Muqddas Tariq, Yiwei Lai, Shahzina Kanwal, Jiajian Zhou, Na Li, Yuan Lv, Carlos Pulido-Quetglas, Xiwei Wang, Lu Ji, Muhammad J Khan, Xihua Zhu, Zhiwei Luo, Changwei Shao, Do-Hwan Lim, Xiao Liu, Nan Li, Wei Wang, Minghui He, Yu-Lin Liu, Carl Ward, Tong Wang, Gong Zhang, Dongye Wang, Jianhua Yang, Yiwen Chen, Chaolin Zhang, Ralf Jauch, Yun-Gui Yang, Yangming Wang, Baoming Qin, Minna-Liisa Anko, Andrew P Hutchins, Hao Sun, Huating Wang, Xiang-Dong Fu, Biliang Zhang,Miguel A Esteban |
2018 Mar; |
Nature Methods |
| Genome-wide DNA methylation analysis reveals that mouse chemical iPSCs have closer epigenetic features to mESCs than OSKM-integrated iPSCs |
Wangfang Ping, Jian Hu, Gongcheng Hu, Yawei Song, Qing Xia, Mingze Yao, Shixin Gong, Cizhong Jiang,Hongjie Yao |
2018 Feb; |
Cell Death & Disease |
