| 論文編號: |
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| 第一作者所在部門: |
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| 中文論文題目: |
Palladium-Catalyzed Modular Synthesis of Enantioenriched Pyridohelicenes through Double Imidoylative Cyclization |
| 英文論文題目: |
Palladium-Catalyzed Modular Synthesis of Enantioenriched Pyridohelicenes through Double Imidoylative Cyclization |
| 作者: |
Ting Yu, Zhong-Qiu Li, Jing Li, Sidi Cheng, Jiali Xu, Jun Huang, Yu-Wu Zhong*, Shuang Luo* and Qiang Zhu* |
| 論文出處: |
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| 刊物名稱: |
ACS Catalysis |
| 年: |
2022 |
| 卷: |
12 |
| 期: |
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| 頁: |
13034-13041 |
| 聯係作者: |
Qiang Zhu |
| 收錄類別: |
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| 影響因子: |
13.700 |
| 摘要: |
Enantioenriched pyrido[6]helicenes and furancontainingpyrido[7]helicenes have been synthesized throughpalladium-catalyzed double imidoylative cyclization by applyingaxially achiral multiaryl bisisocyanides and aryl iodides as couplingcomponents. Two pyridyl rings were constructed sequentially byforming four C？C bonds in one pot with low catalyst loading. Acontrol study using precyclized biaryl monoisocyanides revealedthe second pyridine-forming enantiomer-generating step, which also enabled the introduction of different substituents, includingtrifluoromethyl, on the helical skeleton. This general and convergent approach to structurally diversified optically purepyridohelicenes paves the way for optical studies and potential applications of this important class of azahelicenes.
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| 英文摘要: |
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