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專家人才

  • 姓名：朱強
  • 性別：男
  • 職稱：研究員
  • 學曆：博士
  • 電話：020-32015287
  • 傳真：
  • 電子郵件:zhu_qiang@gibh.ac.cn
  • 通訊地址廣州市蘿崗區科學城開源大道190號B區307

    簡曆：

  • 朱強實驗室網頁

    研究經曆:

    2008年5月至今betway体育下载 PI，研究員

    2005年9月至2008年2月美國公司XTL Biopharmaceuticals Inc. staff scientist

    2001年4月至2005年9月美國公司Vivoquest, Inc. staff scientist

    2000年8月至2001年4月美國科羅拉多州立大學化學係博士後

    教育背景：

    1995年9月至2000年6月中國科學院上海有機化學研究所博士學位

    1991年9月至1995年6月南京大學化學化工學院本科學位

    研究領域：

  • （1）C？H鍵官能化反應用於雜環化合物合成方法研究；

    （2）Cu/O2體係對有機小分子的選擇性氧化；

    （3）異腈參與的新反應研究；

    （4）藥物分子合成工藝的改進；

    （5）抗肺癌，抗肺結核藥物開發。

    承擔科研項目情況：

  • 1．國家自然科學基金科學部主任基金（20942001）“異腈參與的多取代喹啉的合成研究”，2009年1月至2009年12月，8萬元，主持，已結題。

    2．廣州市科技計劃項目（2010Y1-C241）“以鄰炔基苯胺為原料合成幾類重要的含氮雜環”，2011年1月至2011年12月，6萬元，主持，已結題。

    3．國家自然科學基金麵上項目（21072190）“通過分子內C-H鍵官能化合成幾類雜環化合物的新方法研究”，2011年1月至2013年12月，36萬元，主持，已結題。

    4. 2011年廣東省自然科學基金重點項目(S2011020000806)“銅/氧氣體係催化的烯烴脫氫氧胺化反應極其應用研究”，2011年1月至2013年12月，30萬元，主持，已結題。

    5.中國科學院“百人計劃”（人才項目）2011年1月至2013年12月，200萬元，主持，已結題。

    6. 國家自然科學基金麵上項目(21272233)“高價碘試劑催化的氧化環化反應研究”, 2013年至2016年, 80萬元，主持，已結題。

    7．國家自然科學基金青年基金(21202167) “銅/氧氣體係催化的烯烴脫氫氧胺化反應研究” 2013年至2015年，25萬元，課題組成員黃金波博士主持，已結題。

    8. 廣東省自然科學基金(2014A030313796) 2015年至2017年，10萬元，課題組成員黃金波博士主持，已結題。

    9. 中國科學院青年創新促進會（人才項目） 2015年至2018年，60萬元，課題組成員羅爽博士主持，在研。

    10. 國家自然科學基金麵上項目(21472190)“鈀催化的亞胺基化環化反應用於構建雜環化合物的研究”, 2015年至2018年, 95萬元，主持，在研。

    11．國家自然科學基金青年基金(21402203) “過渡金屬催化的雙碳氫鍵的羰基化反應” 2015年至2017年，25萬元，課題組成員羅爽博士主持，已結題。

    12. 國家自然科學基金重點項目項目(21532009)“過渡金屬催化烯烴的氧化官能化新反應研究”, 2016年至2020年, 180 萬元，參與，在研。(上海有機化學研究所劉國生研究員主持，總經費380萬元)

    13. 國家自然科學基金麵上項目(21672215)“吲哚-2-酮-3-螺噻嗪酮類化合物的抗結核活性研究”, 2017年至2020年, 65萬元，課題組成員黃金波博士主持，在研。

    14．國家自然科學基金麵上項目(21772198)“鈀催化的不對稱亞胺基化反應研究”, 2018年至2021年, 64萬元，課題組成員羅爽博士主持，在研。

    社會任職：

    獲獎及榮譽：

  • 1998年，上海有機化學研究所首屆劉鑄晉獎

    2012年，中科院廣州教育基地優秀研究生導師

    2012年，中科院優秀研究生導師獎

    代表論著：

  • 2018年
    59. Cascade double isocyanide insertion and C–N coupling of 2-iodo-2′-isocyano-1,1′-biphenyls
    Hongwei Sun, Shi Tang, Dengke Li, Yali Zhou, Jinbo Huang* and Qiang Zhu*
    Org. Biomol. Chem. 2018, 16, 3893-3896. Impact factor: 3.423

    58. PhI(OAc)2-Mediated Dearomative C–N Coupling: Facile Construction of the Spiro[indoline-3,2’-pyrrolidine] Skeleton
    Yali Zhou, Dengke Li, Shi Tang, Hongwei Sun, Jinbo Huang* and Qiang Zhu*
    Org. Biomol. Chem. 2018, 16, 2039-2042. Impact factor: 3.423

    57. Pd-Catalzed Divergent C(sp2)–H Activation/Cycloimidlylation of 2-Isocyano-2,3-diarylpropanoates
    Shi Tang, Sheng-Wen Yang, Hongwei Sun, Yali Zhou, Juan Li* and Qiang Zhu*
    Org. Lett. 2018, 20, 1832-1836. Impact factor:6.492

    56. Enantioselective Synthesis of Planar Chiral Pyridoferrocenes via
    Palladium-Catalyzed Imidoylative Cyclization Reactions
    Shuang Luo,* Zhuang Xiong, Yongzhi Lu and Qiang Zhu*
    Org. Lett. 2018, 20, 1837-1840. Impact factor:6.492

    55. Stirring-Controlled Mono or Double Aminocarbonylation of 1,3-Bis(2-
    iodoaryl)propan-2-amines
    Huaanzi Hu, Zeqiang Xie, Shuang Luo* and Qiang Zhu*
    Tetrahedron Lett. 2018, 59, 1034-1037. Impact factor:2.125

    2017年
    54. Palladium-Catalyzed Imidoylative Cyclization of Tryptophan-Derived Isocyanides: Access to β-Carbolines
    Shi Tang, Jian Wang, Zhuang Xiong, Zeqiang Xie, Dengke Li, Jinbo Huang* and Qiang Zhu*
    Org. Lett. 2017, 19, 5577-5580. Impact factor:6.492.

    53. Palladium-Catalyzed C(sp2)–H Aminoimidoylation of Isocyano-Containing Arenes: Synthesis of Amino Substituted N-Heterocycles
    Zhuang Xiong, Jian Wang, Yanbo Wang, Shuang Luo* and Qiang Zhu*
    Org. Chem. Front. 2017, 4, 1768-1771. Impact factor:5.455

    52. Copper-Catalyzed Regioselective 1,2-Thioamidation of Alkenes
    Dengke Li, Tingting Mao, Jinbo Huang and Qiang Zhu*
    Chem. Commun. 2017, 53, 3450-3453. Impact factor: 6.290

    51. A One-Pot Synthesis of [1,2,3]Triazolo[1,5-a]quinoxalines from 1-Azido-2-isocyanoarenes with High Bond-Forming E?ciency
    Dengke Li, Tingting Mao, Jinbo Huang and Qiang Zhu*
    Chem. Commun. 2017, 53, 1305-1308. Impact factor: 6.290

    50. Palladium-Catalyzed Enantioselective C(sp2)–H lmidoylation by Desymmetrization
    Jian Wang, De-Wei Gao, Jinbo Huang, Shi Tang, Zhuang Xiong, Huaanzi Hu, Shu-Li You* and Qiang Zhu*
    ACS Catal. 2017, 7, 3832-3836. Impact factor:11.384

    49. Denitrogenative Imidoyl Radical Cyclization: Synthesis of 2 Substituted Benzoimidazoles from 1 Azido-2-isocyanoarenes
    Dengke Li, Tingting Mao, Jinbo Huang and Qiang Zhu*
    Org. Lett. 2017, 19, 3223-3226. Impact factor:6.492

    2016年
    48. Imidoylative Heck Reaction: Synthesis of Cyclic Ketoimines from Functionalized Isocyanide
    Jian Wang, Shi Tang and Qiang Zhu*
    Org. Lett. 2016, 18, 3074-3077.

    47. Transition Metal-Free Amidoalkylation of Benzothiazoles and
    Amidoalkylarylation of Activated Alkenes with N,N-Dialkylamides
    Jian Wang, Jing Li, Jinbo Huang* and Qiang Zhu*
    J. Org. Chem. 2016, 81, 3017-3022.

    46. Pd-Catalyzed C(sp2)–H Carbonylation of 2-Benzylpyridines for the Synthesis of Pyridoisoquinolinones
    Zeqiang Xie, Shuang Luo* and Qiang Zhu*
    Chem. Commun. 2016, 52, 12873-12876.

    45. A Metal-Free Synthesis of 2-Aminobenzothiazoles through Aminyl Radical Addition to Arylisothiocyanates
    Yimiao He, Jing Li, Shuang Luo, Jinbo Huang* and Qiang Zhu*
    Chem. Commun. 2016, 52, 8444-8447.

    44. Copper-Mediated C(sp3)–H Azidation with Me3SiN3: Synthesis of Imidazoles from Ketones and Aldehydes
    Zeqiang Xie, Jiaojiao Deng, Zhiping Qiu, Juan Li* and Qiang Zhu*
    Chem. Commun. 2016, 52, 6467-6470.

    43. Dearomative C–C and C–N Bond Cleavage of 2-Arylindoles: Transition-Metal-Free Access to 2-Aminoarylphenones
    Shuang Luo,* Ziwei Hu and Qiang Zhu*
    Org. Chem. Front. 2016, 3, 364-367.

    42. Copper-Mediated C(sp3)–H Amination in a Multiple C–N Bond-Forming Strategy for the Synthesis of N-heterocycles
    Zeqiang Xie, Jiangling Peng and Qiang Zhu*
    Org. Chem. Front. 2016, 3, 82-86.

    41. Recent Progress in Imydoyl Radical-Involved Reactions
    Jian Lei, Jinbo Huang and Qiang Zhu*
    Org. Biomol. Chem. 2016, 14, 2593-2602.

    2015年
    40. Palladium-Catalyzed Intramolecular C(sp2)–H Imidoylation for the Synthesis of Six-Membered N-Heterocycles
    Jing Li, Yimiao He, Shuang Luo, Jian Lei, Jian Wang, Zeqiang Xie and Qiang Zhu*
    J. Org. Chem. 2015, 80, 2223-2230.

    39. A Facile Synthesis of Pyrazoles through Metal-Free Oxidative C(sp2)–H Cycloamination of Vinyl Hydrazones
    Dongdong Liang and Qiang Zhu*
    Asian J. Org. Chem. 2014, 4, 42-45.

    38. Copper-Catalyzed Tri?uoromethylalkynylation of Isocyanides
    Jian Lei, Xiaoxing Wu* and Qiang Zhu*
    Org. Lett. 2015, 17, 2322-2325.

    37. Copper-Catalyzed Trifluoromethylation of Trisubstituted Allylic and Homoallylic Alcohols
    Jian Lei, Xiaowu Liu, Shaolin Zhang, Shuang Jiang, Minhao Huang, Xiaoxing Wu* and Qiang Zhu*
    Chem. Eur. J. 2015, 21, 6700-6703.

    36. Aminopalladation-Triggered Carbene Insertion Reaction: Synthesis of 2-(1H-Indol-3-yl)acetates
    Ziwei Hu, Shuang Luo* and Qiang Zhu*
    Adv. Synth. Catal. 2015, 357, 1060-1064.

    35. Palladium-Catalyzed Intermolecular C–H Amidation of Indoles with Sulfonyl Azides
    Ziwei Hu, Shuang Luo* and Qiang Zhu*
    Sci. China. Chem. 2015, 58, 1349-1353.

    34. Surface Con?ned Retro Diels-Alder Reaction Driven by the Swelling of Weak Polyelectrolytes
    Beier Lyu, Wenli Cha, Tingting Mao, Yuanzi Wu, Hujun Qian, Qiang Zhu* and Hongwei Ma*
    ACS Appl. Mater. Interfaces 2015, 7, 6254-6259.

    2014年
    33. Arylative Cyclization of 2-Isocyanobiphenyls with Anilines: One-Pot Synthesis of 6-Arylphenanthridines via Competitive Reaction Pathways
    Zhonghua Xia, Jinbo Huang, Yimiao He, Jiaji Zhao, Jian Lei and Qiang Zhu*
    Org. Lett. 2014, 16, 2546-2549.

    32. Palladium-Catalyzed C(sp2)–H Pyridocarbonylation of N-Aryl-2-aminopyridines: Dual Function of the Pyridyl Moiety
    Dongdong Liang, Yimiao He and Qiang Zhu*
    Org. Lett. 2014, 16, 2748-2751.

    31. Palladium-Catalyzed Imidoylative Cyclization of α-Isocyanoacetamides: Efficient Access to C2-Diversified Oxazoles
    Jian Wang, Shuang Luo, Jinbo Huang, Tingting Mao and Qiang Zhu*
    Chem. Eur. J. 2014, 20, 11220-11224.

    30. Copper-Mediated C(sp2)–H Amination Using TMSN3 as a Nitrogen Source: Redox-Neutral Access to Primary Anilines
    Jiangling Peng, Ming Chen, Zeqiang Xie, Shuang Luo and Qiang Zhu*
    Org. Chem. Front. 2014, 1, 777-781.

    29. Copper-Catalyzed C(sp2)–H Amidation with Azides as Amino Sources
    Jiangling Peng, Zeqiang Xie, Ming Chen, Jian Wang and Qiang Zhu*
    Org. Lett. 2014, 16, 4702-4705.

    28. A Room-Temperature Synthesis of 2,2’-Bisoxazoles through Palladium-Catalyzed Oxidative Coupling of α-Isocyanoacetamides
    Jian Wang, Shuang Luo, Jing Li and Qiang Zhu*
    Org. Chem. Front. 2014, 1, 1285-1288.

    27. Copper-Catalyzed Intramolecular Oxidative C(sp3)–H Amidation of 2-Amino- acetophenones: Efficient Synthesis of Indoline-2,3-diones
    Jinbo Huang*, Tingting Mao and Qiang Zhu*
    Eur. J. Org. Chem. 2014, 2878-2882.

    2013年
    26. Synthesis of Phenanthridinones via Palladium-Catalyzed C(sp2)–H Aminocarbonylation of Unprotected o-Arylanilines
    Dongdong Liang, Ziwei Hu, Jiangling Peng, Jinbo Huang and Qiang Zhu*
    Chem. Commun. 2013, 49, 173-175.

    25. Synthesis of 10-Methylacridin-9(10H)-ones through Cu-Catalyzed Intramolecular Oxidative C(sp2)–H Amination of o-N-Methylaminobenzophenones
    Jinbo Huang, Congqing Wan, Ming-Fang Xu* and Qiang Zhu*
    Eur. J. Org. Chem. 2013, 1876-1880.

    24. C–H Cycloamination of N-Aryl-2-aminopyridines and N-Arylamidines Catalyzed by an in situ Generated Hypervalent Iodine(III) Reagent
    Yimiao He, Jinbo Huang, Dongdong Liang, Lanying Liu and Qiang Zhu*
    Chem. Commun. 2013, 49, 7352-7354.

    23. A Metal-Free Tandem Demethylenation/C(sp2)–H Cycloamination Process of N?Benzyl-2-aminopyridines via C–C and C–N Bond Cleavage
    Dongdong Liang, Yimiao He, Lanying Liu and Qiang Zhu*
    Org. Lett. 2013, 15, 3476-3479.

    22. A Transition-Metal-Free Synthesis of Arylcarboxyamides from Aryl Diazonium Salts and Isocyanides
    Zhonghua Xia and Qiang Zhu*
    Org. Lett. 2013, 15, 4110-4113.

    21. Synthesis of 1H-Indole-3-carboxamidines through a Palladium-Catalyzed Three-Component Reaction Involving Isocyanide Insertion as a Key Step
    Ziwei Hu, Jian Wang, Dongdong Liang and Qiang Zhu*
    Adv. Synth. Catal. 2013, 355, 3290-3294.

    2012 年
    20. Direct Carboxamidation of Indoles by Palladium-Catalyzed C–H Activation and Isocyanide Insertion
    Jiangling Peng, Lanying Liu, Ziwei Hu, Jinbo Huang and Qiang Zhu*
    Chem. Commun. 2012, 48, 3772-3774.

    19. Cu-Catalyzed Oxidative C(sp2)–H Cycloetherification of o-Arylphenols for the Preparation of Dibenzofurans
    Jiaji Zhao, Yong Wang, Yimiao He, Lanying Liu, Qiang Zhu*
    Org. Lett. 2012, 14, 1078-1081.

    18. Cu-Catalyzed Regioselective C–H Aerobic Oxidative Cycloetherification of o-Arylphenols Bearing an Additional Directing Group
    Jiaji Zhao, Yong Wang and Qiang Zhu*
    Synthesis 2012, 44, 1551-1555.

    17. Palladium(II)-Catalyzed Cycloamidination via C(sp2)–H Activation and Isocyanide Insertion
    Yong Wang and Qiang Zhu*
    Adv. Synth. Catal. 2012, 354, 1902-1908.

    16. Palladium-Catalyzed Cyclization of o-Alkynyltrifluoroacetanilides Followed by Isocyanide Insertion: Synthesis of 2-Substituted 1H-Indole-3-carboxamides
    Ziwei Hu, Dongdong Liang, Jiaji Zhao, Jinbo Huang and Qiang Zhu*
    Chem. Commun. 2012, 48, 7371-7373.

    15. Palladium-Catalyzed C(sp2)–H Cyanation Using Tertiary Amine Derived Isocyanide as a Cyano Source
    Jiangling Peng, Jiaji Zhao, Ziwei Hu, Dongdong Liang, Jinbo Huang and Qiang Zhu*
    Org. Lett. 2012, 14, 4966-4969.

    14. CuI-Mediated Sequential Iodination/Cycloetherification of o-Arylphenols: Synthesis of 2- or 4-Iododibenzofurans and Mechanistic Studies
    Jiaji Zhao, Qi Zhang, Lanying Liu, Yimiao He, Jing Li, Juan Li* and Qiang Zhu*
    Org. Lett. 2012, 14, 5362-5365.

    13. Synthesis of Benzimidazoles by PIDA-Promoted Direct C(sp2)–H Imidation of N-Arylamidines
    Jinbo Huang, Yimiao He, Yong Wang and Qiang Zhu*
    Chem. Eur. J. 2012, 18, 13964-13967.

    2011 年
    12. Palladium-Catalyzed Intramolecular C(sp2)–H Amidination by Isonitrile Insertion Provides Direct Access to 4-Aminoquinazolines from N-Arylamidines
    Yong Wang, Honggen Wang, Jiangling Peng and Qiang Zhu*
    Org. Lett. 2011, 13, 4604-4607.

    11. Bronsted Acid-Promoted Sequential Hydroarylation-Hydroamidation of Arene Tethered 1-(2-Alkynylphenyl)ureas: Direct Access to 4,4-Spiro-3,4-dihydro-2-(1H)- quinazolinones
    Honggen Wang, Jiaji Zhao, Jiancun Zhang* and Qiang Zhu*
    Adv. Synth. Catal. 2011, 353, 2653-2658.

    10. Sequential Hydration-Condensation-Double Cyclization of Pyridine-Substituted 2-Alkynylanilines: an Efficient Approach to Quinoline-Based Heterocycles
    Lijie Peng, Honggen Wang, Changlan Peng, Ke Ding* and Qiang Zhu*
    Synthesis 2011, 1723-1732.

    9. Synthesis of Quinazolin-4(3H)-ones via Pd(II)-Catalyzed Intramolecular C(sp2)–H Carboxamidation of N-Arylamidines
    Bin Ma, Yong Wang, Jiangling Peng and Qiang Zhu*
    J. Org. Chem. 2011, 76, 6362-6366.

    8. Copper-Catalyzed Intramolecular Dehydrogenative Aminooxygenation: Direct Access to Formyl-Substituted Aromatic N-Heterocycles
    Honggen Wang, Yong Wang, Dongdong Liang, Lanying Liu, Jiancun Zhang* and Qiang Zhu*
    Angew. Chem., Int. Ed. 2011, 50, 5678-5681.

    2010 年
    7. Synthesis of 2-Alkoxy(aroxy)-3-substituted Quinolines by DABCO-Promoted Cyclization of ortho-Alkynylaryl Isocyanides
    Jiaji Zhao, Changlan Peng, Lanying Liu, Yong Wang and Qiang Zhu*
    J. Org. Chem. 2010, 75, 7502-7504.

    6. A Direct Intramolecular C–H Amination Reaction Co-Catalyzed by Copper(II) and Iron(III) as Part of an Efficient Route for the Synthesis of Pyrido[1,2-a]benzimidazoles from N-Aryl-2-aminopyridines
    Honggen Wang, Yong Wang, Changlan Peng, Jiancun Zhang* and Qiang Zhu*
    J. Am. Chem. Soc. 2010, 132, 13217-13219.

    5. p-Toluenesulfonic Acid Promoted Annulation of 2-Alkynylanilines with Activated Ketones: Efficient Synthesis of 4-Alkyl-2,3-Disubstituted Quinolines
    Changlan Peng, Yong Wang, Lanying Liu, Honggen Wang, Jiaji Zhao and Qiang Zhu*
    Eur. J. Org. Chem. 2010, 818-822.
    4. Structure-Based Design, Synthesis and Biological Evaluation of New N-Carboxyphenylpyrrole Derivatives as HIV Fusion Inhibitors Targeting gp41
    Yong Wang, Hong Lu, Qiang Zhu*, Shibo Jiang* and Yun Liao*
    Bioorg. Med. Chem. Lett. 2010, 20, 189-192.

    2009 年
    3. An Efficient Synthesis of 4-Alkyl-2(1H)-quinazolinones and 4-Alkyl-2-chloroquinazolines from 1-(2-Alkynylphenyl)ureas
    Honggen Wang, Lanying Liu, Yong Wang, Changlan Peng, Jiancun Zhang* and Qiang Zhu*
    Tetrahedron Lett. 2009, 50, 6841-6843.

    2. Tetrabutylammonium Chloride-Triggered 6-endo Cyclization of o-Alkynylisocyanobenzenes: an Efficient Synthesis of 2-Chloro-3-Substituted Quinolines
    Lanying Liu, Yong Wang, Honggen Wang, Changlan Peng, Jiaji Zhao and Qiang Zhu*
    Tetrahedron Lett. 2009, 50, 6715-6719.

    1. Sulfuric Acid Promoted Condensation Cyclization of 2-(2-(Trimethylsilyl)ethynyl)anilines with Arylaldehydes in Alcoholic Solvents: an Efficient One-Pot Synthesis of 4-Alkoxy-2-arylquinolines
    Yong Wang, Changlan Peng, Lanying Liu, Jiaji Zhao, Li Su and Qiang Zhu*
    Tetrahedron Lett. 2009, 50, 2261-2265.

    專利：
    1. 吳東海, 朱強, 楊鬆, 劉蘭英, 彭長蘭
    青蒿素衍生物的新應用，ZL201010216620.0

    2. 朱強, 王洪根, 王勇, 梁冬冬, 劉蘭英, 張健存
    咪唑[1,2-a]吡啶和咪唑醛類化合物的新合成方法, 專利號：201110110748.3

    3. 朱強, 張天宇, 劉蘭英, 魯明輝, 毛婷婷，黃金波
    吲哚[3,2-c]喹啉類化合物或其藥學上可接受的鹽及其製備方法和應用, 中國專利號：201310385431.X

    4. 塗正超，朱強，張天宇，黃金波，徐曉冰，萬軍庭，黎敏科，李登科，周亞麗，劉誌永，王邦興，米琦.托特雷拉
    吲哚-2-酮-3-螺噻嗪或噻唑酮化合物及其應用，中國專利號：CN201610657161.7

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