首頁>> 中文>> 專家人才

專家人才

  • 姓名:劉勁鬆
  • 性別:
  • 職稱:研究員
  • 學曆:博士
  • 電話:
  • 傳真:
  • 電子郵件:liu_jinsong@gibh.ac.cn
  • 通訊地址廣州蘿崗區科學城開源大道190號

    簡曆:

  • 1988-6/1992北京大學學士

    1994-1/2000美國羅格斯大學(Rutgers University)博士

    2000 - 2/2000美國羅格斯大學(Rutgers University)博士後

    2000 - 8/2004美國Tularik公司,科學家,助理科學家,資深研究助理

    2004 - 10/2005美國Amgen公司,資深科學家

    2005 -現在betway体育下载 ,研究員

    研究領域:

  • 以結構生物學為主要手段,緊密結合新藥研發,著眼於與人類重大疾病和重要生理功能相關的蛋白質及其複合體的結構與功能的關係,闡明生物大分子與小分子化合物在結構與功能方麵的分子作用機理,為藥物的分子設計提供思路;同時,通過解析生物大分子及其複合物的三維結構,為藥物設計提供一個分子水平上的模板

    承擔科研項目情況:

  • 1.國家重點研發計劃(2017年),項目負責人。

    2.97320122005),項目負責人。

    3.國家自然科學基金麵上項目(2018年、2016年、2012年、2009年),項目負責人。

    4.國家自然科學基金聯合基金項目(2013年),項目負責人。

    5.廣東省自然科學基金團隊項目(2015),項目負責人。

    6.廣州市健康醫療協同創新重大專項(2014,項目負責人。

    社會任職:

  • 呼吸疾病國家重點實驗室副主任

    廣東省生物醫藥計算重點實驗室副主任

    獲獎及榮譽:

    代表論著:

  • 1.Xu T.*, Gan Q., Wu B., Yin M., Xu J., Shu X.,Liu J.*. Molecular Basis for PI(3,5)P2 Recognition by SNX11, a Protein Involved in Lysosomal Degradation and Endosome Homeostasis Regulation. J Mol Biol 2020, 432(16): 4750-4761.

    2.Xu J.#*, Tang X.#, Zhu Y., Yu Z., Su K., Zhang Y., Dong Y., Zhu W., Zhang C., Wu R.,Liu J.*. Structural studies reveal flexible roof of active site responsible for omega-transaminase CrmG overcoming by-product inhibition. Commun Biol 2020, 3(1): 455.

    3.Makafe, G. G.#, Hussain, M.#, Surineni, G., Tan, Y., Wong, N. K., Julius, M., Liu, L., Gift, C., Jiang, H., Tang, Y., Liu, J., Tan, S., Yu, Z., Liu, Z., Lu, Z., Fang, C., Zhou, Y., Zhang, J., Zhu, Q.,Liu, J.* and Zhang, T.* Quinoline Derivatives Kill Mycobacterium tuberculosis by Activating Glutamate Kinase. Cell Chem Biol 2019, 26, 1187-1194 e1185

    4.Hussain, M.#, Adah, D.#, Tariq, M., Lu, Y., Zhang, J.* andLiu, J.* CXCL13/CXCR5 signaling axis in cancer. Life Sci 2019, 227, 175-186

    5.Xu T, Zhou CZ, Xiao J.*,Liu J.* Unique Conformation in a Natural Interruption Sequence of Type XIX Collagen Revealed by Its High-Resolution Crystal Structure. Biochemistry 2018, 57(7): 1087-1095

    6.Wang N, Zou Q, Xu J, Zhang J,Liu J.* Ligand binding and heterodimerization with retinoid X receptor alpha (RXRalpha) induce farnesoid X receptor (FXR) conformational changes affecting coactivator binding. The Journal of biological chemistry 2018, 293(47): 18180-18191

    7.Xu T., Xie C., Yao D., Zhou CZ.,Liu J.*. Crystal structures of Aflatoxin-oxidase from Armillariella tabescens reveal a dual activity enzyme. Biochemical and biophysical research communications 2017, 494(3-4): 621-625

    8.Xu J#, Zhang L#, Ye Y, Shan Y, Wan C, Wang J, Pei D, Shu X.*,Liu J.* SNX16 Regulates the Recycling of E-Cadherin through a Unique Mechanism of Coordinated Membrane and Cargo Binding. Structure 2017, 25(8): 1251-1263 e1255

    9.Hou S, Xu T, Xu J, Qu L, Xu Y, Chen L,Liu J*. Structural basis for functional selectivity and ligand recognition revealed by crystal structures of human secreted phospholipase A2 group IIE. Scientific reports 2017, 7(1): 10815

    10.Zhu Y#, Xu J#, Mei X#, Feng Z, Zhang L, Zhang Q, Zhang G, Zhu W*,Liu J*, Zhang C*. Biochemical and Structural Insights into the Aminotransferase CrmG in Caerulomycin Biosynthesis. ACS chemical biology 2016, 11(4): 943-952

    11.Hussain M, Lu Y, Liu YQ, Su K, Zhang J,Liu J*, Zhou GB*. Skp1: Implications in cancer and SCF-oriented anti-cancer drug discovery. Pharmacological research 2016, 111: 34-42

    12.Zhu L, Yang J, Li H, Sun H,Liu J*, Wang J*. Conformational change study of dengue virus NS2B-NS3 protease using (19)F NMR spectroscopy. Biochemical and biophysical research communications 2015, 461(4): 677-680

    13.Liu YQ#, Wang XL#, Cheng X#, Lu YZ#, Wang GZ#, Li XC, Zhang J, Wen ZS, Huang ZL, Gao QL, Yang LN, Cheng YX*, Tao SC,Liu J*, Zhou GB*. Skp1 in lung cancer: clinical significance and therapeutic efficacy of its small molecule inhibitors. Oncotarget 2015, 6(33): 34953-34967

    14.Guo S#, Xu J#, Pavlidis IV, Lan D, Bornscheuer UT,Liu J*, Wang Y*. Structure of product-bound SMG1 lipase: active site gating implications. The FEBS journal 2015, 282(23), 4538-4547

    15.Xu T, Xu J, Ye Y, Wang Q, Shu X, Pei D,Liu J*. Structure of human SNX10 reveals insights into its role in human autosomal recessive osteopetrosis. Proteins 2014, 82(12): 3483-3489

    16.Mei G, Dong J, Li Z, Liu S, Liu Y, Sun M, Liu G, Su Z*,Liu J*. Structural basis for the immunomodulatory function of cysteine protease inhibitor from human roundworm Ascaris lumbricoides. PloS one 2014, 9(4): e96069

    17.Li H, Zhu L, Hou S, Yang J, Wang J*,Liu J*. An inhibition model of BPTI to unlinked dengue virus NS2B-NS3 protease. FEBS letters 2014, 588(17): 2794-2799

    18.Xu J, Xu T, Wu B, Ye Y, You X, Shu X, Pei D,Liu J*. Structure of sorting nexin 11 (SNX11) reveals a novel extended phox homology (PX) domain critical for inhibition of SNX10-induced vacuolation. The Journal of biological chemistry 2013, 288(23): 16598-16605

    19.Xu T#, Liu L#, Hou S, Xu J, Yang B, Wang Y*,Liu J*. Crystal structure of a mono- and diacylglycerol lipase from Malassezia globosa reveals a novel lid conformation and insights into the substrate specificity. J Struct Biol 2012, 178(3): 363-369

    20.Liu J#, Sudom A#, Min X#, Cao Z, Gao X, Ayres M, Lee F, Cao P, Johnstone S, Plotnikova O, Walker N, Chen G, Wang Z. Structure of the nuclear factor kappaB-inducing kinase (NIK) kinase domain reveals a constitutively active conformation. The Journal of biological chemistry 2012, 287(33): 27326-27334

    21.Bi Y, Zhu L, Li H, Wu B,Liu J*, Wang J*. Backbone (1)H, (13)C and (15)N resonance assignments of dengue virus NS2B-NS3p in complex with aprotinin. Biomol NMR Assign 2012, 7:137-139

    22.Zhang Y, Xu T, Chen Q, Wang B,Liu J*. Expression, purification, and refolding of active human and mouse secreted group IIE phospholipase A. Protein Expr Purif 2011, 80(1): 68-73

    23.Wang Y, Wang Q, Zhu Q, Zhou R,Liu J*, Peng T*. Identification and characterization of acyclovir-resistant clinical HSV-1 isolates from children. J Clin Virol 2011, 52(2): 107-112

    24.Lu N, Wang W,Liu J*, Wong CW*. Protein kinase C epsilon affects mitochondrial function through estrogen-related receptor alpha. Cell Signal 2011, 23(9): 1473-1478

    25.Liu S, Dong J, Mei G, Liu G, Xu W, Su Z,Liu J*. Crystallization and preliminary crystallographic studies of a cysteine protease inhibitor from the human nematode parasite Ascaris lumbricoides. Acta Crystallogr Sect F Struct Biol Cryst Commun 2011, 67(Pt 2): 228-230

    26.Liu Q, Shen Y, Liu S, Weng J,Liu J*. Crystal structure of E339K mutated human glucokinase reveals changes in the ATP binding site. FEBS letters 2011, 585(8): 1175-1179

    27.Gong L, Xiao Y, Liu Q, Li S, Zhang C,Liu J*. Preliminary X-ray crystallographic analysis of the glycosyltransferase from a marine Streptomyces species. Acta Crystallogr Sect F Struct Biol Cryst Commun 2011, 67(Pt 1): 136-139

    28.Gao M#, Wang J#, Lu N#, Fang F,Liu J*, Wong CW*. Mitogen-activated protein kinase kinases promote mitochondrial biogenesis in part through inducing peroxisome proliferator-activated receptor gamma coactivator-1beta expression. Biochimica et biophysica acta 2011, 1813(6): 1239-1244

    29.Xu W#, Yi L#, Feng Y, Chen L*,Liu J*. Structural insight into the activation mechanism of human pancreatic prophospholipase A2. The Journal of biological chemistry 2009, 284(24): 16659-16666.

    30. Bella J#,Liu J#, Kramer R, Brodsky B, Berman HM*. Conformational effects of gly-x-gly interruptions in the collagen triple helix. J Mol Biol 2006, 362(2): 298-311.

    30.Wang Z#, Benoit G#,Liu J, Prasad S, Aarnisalo P, Liu X, Xu H, Walker NP*, Perlmann T*. Structure and function of Nurr1 identifies a class of ligand-independent nuclear receptors. Nature 2003, 423(6939): 555-560.

    31.Benoff B, Yang H, Lawson CL, Parkinson G,Liu J, Blatter E, Ebright YW, Berman HM*, Ebright RH*. Structural basis of transcription activation: the CAP-alpha CTD-DNA complex. Science 2002, 297(5586): 1562-1566.

    32.Liu J, Lynch PA, Chien CY, Montelione GT, Krug RM, Berman HM*. Crystal structure of the unique RNA-binding domain of the influenza virus NS1 protein. Nat Struct Biol 1997, 4(11): 896-899.

Baidu
map