專家人才
- 姓名:李誌遠
- 性別:男
- 職稱:研究員
- 學曆:博士
- 電話:
- 傳真:
- 電子郵件:li_zhiyuan@gibh.ac.cn
- 通訊地址廣州蘿崗區科學城開源大道190號
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- 1997年獲中南大學藥理學博士學位,並赴日留學
2000年獲得日本德島大學(Tokushima University)博士學位 - 2000-2002年 在美國範德堡大學(Vanderbilt University)藥理學係從事博士後研究
2002-2007年 在美國聖路易斯大學(Saint Louis University)醫學院從事研究工作,擔任助理教授
- 1997年獲中南大學藥理學博士學位,並赴日留學
簡曆:
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幹細胞的基礎研究及臨床應用;
由iPS分化而成的神經元離子通道特征研究;
P2X離子通道的功能研究;
TRPV在細胞運輸及腫瘤調控機製的研究;
離子通道藥物篩選與安全性評估
研究領域:
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國家自然基金麵上項目;
國家重大科學計劃幹細胞973計劃專項項目;
廣東省科技廳前沿探索項目;
廣東省科技廳產學研合作項目
承擔科研項目情況:
社會任職:
獲獎及榮譽:
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1.Li S; Zhao H; Han X; Ni B; He L; Mukama O; Habimana JDD; Lin Z; Huang R; Huang H; Tian C; Tang F;Li Z. (2021) Generation of UCiPSCs-derived neurospheres for cell therapy and its application.Stem Cell Research & Therapy.EMID:c6b60f30551c5c29.
2.Liao Z, Yang X, Wang W, Deng W, Zhang Y, Song A, Ni B, Zhao H, Zhang S,Li Z. (2021) hucMSCs transplantation promotes locomotor function recovery, reduces apoptosis and inhibits demyelination after SCI in rats.Neuropeptides. 86 (2021) 102125.
3.Zhao H, Li S, Lin Z, He L, Deng W, Han X, Tang F, Cheng N, Zhou P, Huang R, Deng S, Huang J,Li Z. (2020). A heterozygous SCN1A (c.A5768G/+) mutant human induced pluripotent stem cell line (USTCi002-A) generated using TALEN-mediated precise gene editing.Stem Cell Res.49, 102058.
4.Zhao H, He L, Huang H, Li S, Cheng N, Tang F, Han X, Lin Z, Huang R, Zhou P, Deng S, Huang J,Li Z. (2020). Generation of a tdTomato-GAD67 reporter human epilepsia mutation induced pluripotent stem cell line, USTCi001-A-2, using CRISPR/Cas9 editing. Stem Cell Res. 48:102003
5.Zhou P, Xie W, Huang HL, Huang R, Tian C, Zhu H, Dai Y,Li Z. (2020). circRNA_100859 functions as an oncogene in colon cancer by sponging the miR-217-HIF-1α pathway.Aging(Albany NY). 12(13):13338-13353.
6.Cheng N, Liu Y, Mukama O , Han X, Huang H, Li S, Zhou P, Lu X,Li Z. (2020). A signal-enhanced and sensitive lateral flow aptasensor for the rapid detection of PDGF-BB.RSC Adv. 10, 18601.
7.Zhao H, He L, Li S, Huang H, Tang F, Han X, Lin Z, Tian C, Huang R, Zhou P, Huang J, Deng S,Li Z. (2020). Generation of corrected-hiPSC (USTCi001-A-1) from epilepsy patient iPSCs using TALEN-mediated editing of the SCN1A gene.Stem Cell Res. 46:101864.
8.Tian C, Han X, He L, Tang F, Huang R, Lin Z, Li S, Deng S, Xu J, Huang H, Zhao H,Li Z. (2020). Transient receptor potential ankyrin 1 contributes to the ATP-elicited oxidative stress and inflammation in THP-1-derived macrophage.Molecular and cellular biochemistry, 473(1-2):179-192.
9.Tian C, Li S, He L, Han X, Tang F, Huang R, Lin Z, Deng S, Xu J, Huang H, Zhao H,Li Z. (2020) Transient receptor potential ankyrin 1 contributes to the lysophosphatidylcholine-induced oxidative stress and cytotoxicity in OLN-93 oligodendrocyte.Cell Stress Chaperones. doi: 10.1007/s12192-020-01131-y.
10.Zhao H, Li S, He L, Han X, Huang H, Tang F, Lin Z, Deng S, Tian C, Huang R,Li Z. (2020). Generation of iPSC line (USTCi001-A) from human skin fibroblasts of a patient with epilepsy.Stem Cell Res. 45:101785.
11.Tian C, Huang R, Tang F, Lin Z, Cheng N, Han X, Li S, Zhou P, Deng S, Huang H, Zhao H, Xu J,Li Z. (2020). Transient Receptor Potential Ankyrin 1 Contributes to Lysophosphatidylcholine-Induced Intracellular Calcium Regulation and THP-1-Derived Macrophage Activation.J Membr Biol. 253(1):43-55.
12.He L, Zhao H, Li S, Han X, Chen Z, Wang C , Tian C, Tang F, Huang R, Lin Z,Li Z, Tang B, Jiang H.(2020).Generation of Induced Pluripotent Stem Cell Line (CSUXHi002-A) From a Patient With Spinocerebellar Ataxia Type 1.Stem Cell Res. 45:101816.
13.Mukama O, Yuan T, He Z,Li Z, Habimana J, Hussain M, Li W, Yi Z, Liang Q, Zeng L.(2020).A high fidelity CRISPR/Cas12a based lateral flow biosensor for the detection of HPV16 and HPV18. Sensors and Actuators B:Chemical. 316: 128119.
14.Mukama O, Wu j,Li Z, Liang Q, Yi Z, Lu X, Liu Y, Liu Y, Hussain M, Makafe G, Liu J, Xu N, Zeng L.(2020).An ultrasensitive and specific point-of-care CRISPR/Cas12 based lateral flow biosensor for the rapid detection of nucleic acids.Biosensors and Bioelectronics. 159: 112143.
15.Huang H , Li C, Ma W, Yin S, Zhao H, Deng S, Shu X, Wu D, Liu D, Huang R, Cheng N, Huang J,Li Z. (2019). Sorting Nexin 11 (SNX11) Knockout Mice Exhibit Enhanced Thermosensing Behaviour.Genes Brain and Behavior. e12625.
16.He L, Ye W, Chen Z, Wang C, Zhao H, Li S, Peng L, Han X, Zhou T,Li Z, Tang B, Jiang H. (2019) Generation of an induced pluripotent stem cell line (XHCSUi001-A) from urine cells of a patient with spinocerebellar ataxia type 3.Stem Cell Res. 40:101555.
17.Li S, Zhao H, Huang R, He L, Tian C, Huang H, Han B, Tang F, Lin Z, Deng S, Zhou J,Li Z. (2019). Generation of iPSC line (GIBHi001-A) from a patient with autism spectrum disorder.Stem Cell Res. 40, 101571.
18.Huang R, Wang F, Yang Y, Ma W, Lin Z, Cheng N, Long Y, Deng S,Li Z. (2019) Recurrent activations of transient receptor potential vanilloid-1 and vanilloid-4 promote cellular proliferation and migration in esophageal squamous cell carcinoma cells.FEBS Open Bio. 18;9(2):206-225.
19.Wang F, Cheng N, Chen J, Yang Y, Huang R, Huang H, Lin Z, Tian C, Zhao H, Long Y,Li Z. (2019) Promoting Osteogenesis of Human Umbilical Cord Mesenchymal Stem Cells Using 1α, 25-(OH)2D3 to Change Intracellular Calcium Concentration.J Nanosci. Nanotechnol. 19(9):5435-5440.
20.Ji S, Lin S, Chen J, Huang X, Wei C, Tang S,Li Z. (2018) Neuroprotection of Transplanting Human Umbilical Cord Mesenchymal Stem Cells in a Microbead Induced Ocular Hypertension Rat Model.Current Eye Research. 1460-2202
21.Lei Y, Chen C, Yan X,Li Z, Deng X. (2017) Early-life lipopolysaccharide exposure potentiates forebrain expression of NLRP3 inflammasome proteins and anxiety-like behavior in adolescent rats.Brain Research. 15;1671:43-54.
22.Zhong X, Deng S, Ma W, Yang Y, Lu D, Cheng N, Chen D, Wang H, Zhang J, Li F, Li C, Huang H,Li Z. (2017) Anterior cingulate cortex involved in social food-foraging decision-making strategies of rats.Brain Behav. 7(10):e00768.
23.Li C, Ma W, Yin S, Liang X, Shu X, Pei D, Egan TM, Huang J, Pan A,Li Z. (2016) Sorting Nexin 11 Regulates Lysosomal Degradation of Plasma Membrane TRPV3.Traffic. 17(5):500-14.
24.Liu J, Gao C, Chen W, Ma W, Deng S, Li X, Shi Y, Zhang H, Zhang L, Long Y, Xu H, Guo X, Lai L, Pan G, Chen Y, Liao W,Li Z(2016) CRISPR/Cas9 Facilitates Investigation of Neural Circuit Disease using Human iPSCs: Mechanism of Epilepsy Caused by an SCN1A Loss-of-function Mutation.Translational Psychiatry. Jan 5;6:e703.
25.Long Y, Miao X, Rong L, Sheng D, Jeanette B, Guokai C, Ferri S, Ulrich B, Wang M, Marugan J, Muro S,Li Z, Brady R, Zheng W. (2016) Induced Pluripotent Stem Cells for Disease Modeling and Evaluation of Therapeutics for Niemann-Pick Disease Type A.Stem Cells Translational Medicine. 2016;5:1–12
26.Ma W, Li C, Yin S, Liu J, Gao C, Lin Z, Huang R, Huang J,Li Z. (2015) Novel role of TRPV2 in promoting the cytotoxicity of H2O2-mediated oxidative stress in Human hepatoma cells.Free Radical Biology & Medicine.89: 1003–13.
27.He X, Deng F, Ge Jin, Yan X, Pan A,Li Z. (2015) Effects of total saponins of Panax notoginseng on immature neuroblasts in the adult olfactory bulb following global cerebral ischemia/reperfusion.Neural Regeneration Research. 10(9):1450-6.
28.Yang Y, Xie M, Li J, Hu X, Patrylo PR, Luo X, Cai Y,Li Z, Yan X. (2015). Prenatal genesis of layer II doublecortin expressing neurons in neonatal and young adult guinea pig cerebral cortex.Front Neuroanat. 9, 109.
29.Zhou Y, Hou G, He S, Xiao Z, Xu H, Qiu Y, Jiang S, Zheng H,Li Z. (2015) Psora-4, a Kv1.3 Blocker, enhances differentiation and maturation in neural progenitor cells.CNS Neuroscience & Therapeutics21(7):558-67.
30.Gao C, Yu Q, Xu H, Zhang L, Liu J, Jie Y, Ma W, Samways DS,Li Z. (2015) Roles of the lateral fenestration residues of the P2X4 receptor that contribute to the channel function and the deactivation effect of ivermectin.Purinergic Signal. PMID: 25847072
31.Wang X, Zhong X, Li Z, Wang H, Zhang J, Li F, Zhang J, Dai R, Zhou X, Li C,Li Z, Bi F. (2015) Differential roles of hippocampal glutamatergic receptors in neuropathic anxiety-like behavior after partial sciatic nerve ligation in rats.BMC Neurosci.16: 14.
32.Liu C, Yang Y, Hu X, Li J, Zhang X, Cai Y,Li Z, Yan X. (2015). Ontogenesis of NADPH-diaphorase positive neurons in guinea pig neocortex.Front Neuroanat. 9, 11.
33.Zhang L, Deng S,Li Z. (2015) ATP Binding and Channel Activation in P2X Receptors.Receptors & Clinical Investigation. 2(1), 10-14800.
34.Deng S, Hou G, Xue Z, Zhang L, Zhou Y, Liu C, Liu Y,Li Z. (2015) Vitamin E isomer δ-tocopherol enhances the efficiency of neural stem cell differentiation via L-type calcium channel.Neurosci Lett. 12;585C:166-