• 1988-1994學士學位， 醫學與外科學專業 納瓦拉大學 （Pamplona, 西班牙）
  1999-2003博士學位， 生物化學與分子生物學專業 馬德裏自治大學 （西班牙）
  
  
• 1991-1992納瓦拉大學病理學係，研究助理
  1992-1993 納瓦拉大學微生物學係，研究助理（納瓦拉大學是西班牙最知名的醫科類大學）
  1995-1998免疫學臨床專業資格 (需通過國家水平考試)公主醫院 （馬德裏，西班牙）急症科夜間輪值醫生
  2004-2007倫敦帝國學院醫學部腎髒實驗室，副研究員（主任：Patrick Maxwell教授）
  2007年12月 加入廣州生物醫藥與健康研究院，從事腫瘤幹細胞研究

• Metabolism and cell cycle control in embryonic stem cells.
• Molecular pathways underlying the generation of induced pluripotent stem (iPS) cells from somatic cells.
• Effects of altered oxygenation (hypoxia) on embryonic and cancer stem cell behavior.

• 博士前獎學金BEFI獎(2001), 卡洛斯三世衛生機構
• 博士前獎學金FPI獎(1999)， 馬德裏自治區
• 短期訪問研究獎(2002) ， 卡洛斯三世衛生機構(倫敦帝國學院，腎髒實驗室，為期6個月的訪問研究)
• 訪問研究獎(2003)), Wellcome Trust基金會，獎金金額超過￡90,000；項目名稱: ‘Enzyme-substrate interactions underlying the hydroxylation of Hypoxia-Inducible Factor by oxygen dependent-dioxygenases’
• 英國一聯合癌症研究項目負責人之一（2004），項目經費超過￡50,000；項目名稱: ‘Role of the von Hippel-Lindau tumour suppressor in regulating intercellular adhesion’
• 英國一聯合癌症研究項目負責人之一（2006），項目經費超過￡100,000；項目名稱: ‘Role of Hypoxia-Inducible Factor in controlling epithelial-to-mesenchymal transitions’

*Corresponding author

1-Sarah K. Harten, Deepa Shukla, Ravi Barod, Alexander Hergovich, Maria Balda, Karl Matter, andEsteban MA*andPatrick H. Maxwell.Regulation of Renal Epithelial Tight Junctions by the von Hippel-Lindau Tumor Suppressor Gene Involves Occludin and Claudin 1 and Is Independent of E-Cadherin.Molecular Biology of the Cell2009. 20: 1089-1101.

2-Esteban MA,Xu J,Yang J,Peng M,Qin D,Li W,Jiang Z,Chen J,Deng K,Zhong M,Cai J,Lai L,Pei D.Generation of induced pluripotent stem cell lines from Tibetan miniature pig.Journal of Biological Chemistry2009.284:17634-40.

3-Esteban MA,Wang T,Qin B,Yang J,Qin D,Cai J,Li W,Weng Z,Chen J,Ni S,Chen K,Li Y,Liu X,Xu J,Zhang S,Li F,He W,Labuda K,Song Y,Peterbauer A,Wolbank S,Redl H,Zhong M,Cai D,Zeng L,Pei D.Vitamin C Enhances the Generation of Mouse and Human Induced Pluripotent Stem Cells.Cell Stem Cell2010. 6(1): 71-79.Cover story, most read article of the month in Cell Stem Cell after 4 days of publication online

4-Li R,Liang J,Ni S,Zhou T,Qing X,Li H,He W,Chen J,Li F,Zhuang Q,Qin B,Xu J,Li W,Yang J,Gan Y,Qin D,Feng S,Song H,Yang D,Zhang B,Zeng L,Lai L,Esteban MA*,Pei D.A mesenchymal-to-epithelial transition initiates and is required for the nuclear reprogramming of mouse fibroblasts.Cell Stem Cell 2010.7 (1):51-63.Among top ten scientific articles of the year in China

5-Xu J,Li H,Wang B,Xu Y,Yang J,Zhang X,Harten SK,Shukla D,Maxwell PH,Pei D,Esteban MA*.VHL Inactivation Induces HEF1 and Aurora Kinase A.Journal of the American Society of Nephrology2010. 21(12): 2041-2046.

6-Yang J,Cai J,Zhang Y,Wang X,Li W,Xu J,Li F,Guo X,Deng K,Zhong M,Chen Y,Lai L,Pei D,Esteban MA*.Induced pluripotent stem cells can be used to model the genomic imprinting disorder Prader-Willi syndrome.Journal of Biological Chemistry2010. 285(51):40303-11.

7-Cai J,Li W,Su H,Qin D,Yang J,Zhu F,Xu J,He W,Guo X,Labuda K,Peterbauer A,Wolbank S,Zhong M,Li Z,Wu W,So KF,Redl H,Zeng L,Esteban MA*,Pei D.Generation of human induced pluripotent stem cells from umbilical cord matrix and amniotic membrane mesenchymal cells.Journal of Biological Chemistry2010.285(15):11227-34.

8-Ho JC,Zhou T,Lai WH,Huang Y,Chan YC,Li X,Wong NL,Li Y,Au KW,Guo D,Xu J,Siu CW,Pei D,Tse HF,Esteban MA*. Generation of induced pluripotent stem cell lines from 3 distinct laminopathies bearing heterogeneous mutations in lamin A/C.AGING2011. 22(7): 1221-8.

9-Liao B,Bao X,Liu L,Feng S,Zovoilis A,Liu W,Xue Y,Cai J,Guo X,Qin B,Zhang R,Wu J,Lai L,Teng M,Niu L,Zhang B,Esteban MA*,Pei D.Microrna cluster 302-367 enhances somatic cell reprogramming by accelerating a mesenchymal-to-epithelial transition.Journal of Biological Chemistry2011.286(19): 17359-64.

10-Zhou T,Benda C,Dunzinger S,Huang Y,Ho JC,Yang J,Wang Y,Zhang Y,Zhuang Q,Li Y,Bao X,Tse HF,Grillari J,Grillari-Voglauer R,Pei D,Esteban MA*.Generation of human induced pluripotent stem cells from urine.Journal of the American Society of Nephrology2011. 22(7): 1221-8.

11-Zhang S,Chen S,Li W,Guo X,Zhao P,Xu J,Chen Y,Pan Q,Liu X,Zychlinski D,Lu H,Tortorella MD,Schambach A,Wang Y,Pei D,Esteban MA*. Rescue of ATP7B function in hepatocyte-like cells from Wilson’s disease induced pluripotent stem cells using gene therapy or the chaperone drug curcumin.Human molecular genetics2011. 20(16): 3176-87.

12-J Xu, B Wang, Y Xu, L Sun, W Tian, D Shukla, R Barod, J Grillari, R Grillari-Voglauer, PH Maxwell andEsteban MA*.Epigenetic regulation of HIF-1a in renal cancer cells involvesHIF-1a/2a binding to a reverse hypoxia-response element.Oncogene2011.31(8):1065-72.

13-Wang T,Chen K,Zeng X,Yang J,Wu Y,Shi X,Qin B,Zeng L,Esteban MA,Pan G,Pei D.Histone Demethylases Jhdm1a/1b EnhanceSomaticCell Reprogramming in a Vitamin C Dependent Manner.CellStemCell2011. 9(6): 575-587.

14-Li W,Wang X,Fan W,Zhao P,Chan YC,Chen S,Zhang S,Guo X,Zhang Y,Li Y,Cai J,Qin D,Li X,Yang J,Peng T,Zychlinski D,Hoffmann D,Zhang R,Deng K,Ng KM,Menten B,Zhong M,Wu J,Li Z,Chen Y,Schambach A,Tse HF,Pei D,Esteban MA*.Modeling Abnormal Early Development with Induced Pluripotent Stem Cells from Aneuploid Syndromes.Human molecular genetics2012.21(1):32-35.

15-Esteban MA*, Pei D. Vitamin C improves the quality of somatic cell reprogramming.Nature Genetics 2012.44(4):36-7.

16-Zhou T,Benda C,Dunzinger S,Huang Y,Ho JC,Yang J,Wang Y,Zhang Y,Zhuang Q,Li Y,Bao X,Tse HF,Grillari J,Grillari-Voglauer R,Pei D,Esteban MA*. Aprotocol for generating human induced pluripotent stem cells from urine samples.Nature protocol2012.10:2080-9

17-Esteban MA, Bao X, Zhuang Q, Qin B, Pei D. The mesenchymal-to-epithelial transition in somatic cell reprogramming.Current Opinion in Genetics & Development2012.22(5):423-8.

18-Tian W, CuiF,Esteban MA*. E2F1 in renal cancer: Mr Hyde disguised as Dr Jekyll?Journal of Pathology2013.231: 143–146

19-Zhuang Q,Qing X,Ying Y,Wu H,Benda C,Lin J,Huang Z,Liu L,Xu Y,Bao X,Qin B,Pei D,Esteban MA*.Class IIa histone deacetylases and myocyte enhancer factor 2 proteins regulate the mesenchymal-to-epithelial transition of somatic cell reprogramming.Journal of Biological Chemistry2013. 288(17) 12022-31.

20-Bao X,Zhu X,Liao B,Benda C,Zhuang Q,Pei D,Qin B,Esteban MA*.MicroRNAs in somatic cell reprogramming.Current Opinion in Cell Biology2013. 25(2):208-14.

21-Xu Y,Liu L, Laslett AL,Esteban MA*.CellReprogramming:into the groove.Nature Materials.2013. 12:1082-1084.(News and Views)

22-Tian W,Wang Y,Xu Y,Guo X,Wang B,Sun L,Liu L,Cui F,Zhuang Q,Bao X,Schley G,Chung TL,Laslett AL,Willam C,Qin B,Maxwell PH,Esteban MA*.Hypoxia-Inducible Factor Renders Cancer Cells More Sensitive to Vitamin C-Induced Toxicity.Journal of Biological Chemistry2014.289(6): 3339-51.

23-WangY, FanN, TianW, CuiF, NewsomePN, FramptonJ,Esteban MA*and LaiL.Generation of knockout rabbits using transcription activator-like effector nucleases.Cell Regeneration2014.3:3