專家人才
- 姓名:劉興國
- 性別:男
- 職稱:研究員
- 學曆:博士
- 電話:
- 傳真:
- 電子郵件:liu_xingguo@gibh.ac.cn
- 通訊地址廣州市開源大道190號
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2002年-2006年:清華大學生物科學與技術係,博士
1998年-2002年:山東大學生命科學學院,學士
2007年-2010年: Thomas Jefferson University,博士後
2010年-至今:betway体育下载 研究員
簡曆:
·幹細胞命運調控中的核與線粒體等細胞器重塑
·人類線粒體疾病的病理與幹細胞治療
研究領域:
承擔科研項目情況:
“Science Bulletin(《科學通報》英文版)執行編委
亞洲線粒體研究與醫學學會
常務理事 中國生物物理學會
常務理事
社會任職:
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·國家自然科學“傑出青年“基金
·國家重點研發計劃首席科學家
·廣東省科學技術獎自然科學一等獎(第一完成人)
·樹蘭醫學青年獎
·國家自然科學優秀青年基金
·長江學者獎勵計劃青年學者
·2016年幹細胞青年研究員獎
·廣東省特支計劃-科技創新“領軍人才”
·廣東省自然科學傑出青年基金獲得者(首屆)
·國際生物物理學會"2011 Young Bioenergeticist award"
·中國科學院廣州教育基地優秀研究生導師
·中國科學院廣州分院優秀青年科學家
·臻溪生命科學優秀教育工作者獎教金
獲獎及榮譽:
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1.Ying, Z., Xiang G., Zheng, L., …Liu, X*.(2018).Short-term mitochondrial permeability transition pore opening modulates histone lysine methylation at the early phase of somatic cell reprogramming.Cell Metabolism, 28(6):935-945.
2.Ying, Z., Chen K., Zheng, L., …Liu, X*.(2016).Transient activation of mitoflashes modulates Nanog at the early phase of somatic cell reprogramming.Cell Metabolism,23(1):220-226.
3.Li, L., Chen, K., Wang, T., …Liu, X*. (2020). Glis1 facilitates induction of pluripotency via an epigenome-metabolome-epigenome signaling cascade.Nature Metabolism2(9):882-892.
4.Long, Q., Zhou, Y., Wu, H., …Liu, X*. (2021). Phase separation drives the self-assembly of mitochondrial nucleoids for transcriptional modulation.Nature Structural & Molecular Biology28(11):900-908.
5.Li, W.,Long, Q., Wu, H., …Liu, X*. (2022). Nuclear localization of mitochondrial TCA cycle enzymes modulates pluripotency viahistone acetylation.Nature Communications,2022 Dec 2;13(1):7414. doi: 10.1038/s41467-022-35199-0
6.Bao, F., Zhou, L., Zhou, R., …Tian, M*&Liu, X*. (2022). Mitolysosome exocytosis, a mitophagy-independent mitochondrial quality control in flunarizine-induced parkinsonism-like symptoms.Science Advances, 8(15):eabk2376.
7.Wu, Y., Chen, K., Xing, G., …Liu, X*. (2019). Phospholipid remodeling is critical for stem cell pluripotency via facilitating mesenchymal-to-epithelial transition.Science Advances, 5(11):eaax7525.
8.Guo, J.,Duan, L., He, X., …Liu, X*. (2021).A combined model of human iPSC-derived liver organoids and hepatocytes reveals ferroptosis in DGUOK mutant mtDNA depletion syndrome.AdvancedScience8(10):2004680. (封麵)
9.Li, S., Guo, J., Ying, Z., ... Liu, X*. (2015). Valproic acid‐induced hepatotoxicity in Alpers syndrome is associated with mitochondrial permeability transition pore opening‐dependent apoptotic sensitivity in an induced pluripotent stem cell model.Hepatology, 61(5):1730-1739.
10.Chen, K., Long, Q., Xing, G., …Pei, D*&Liu, X*. (2020). Heterochromatin loosening by the Oct4 linker region facilitates Klf4 binding and iPSC reprogramming.EMBO Journal, 39(1):e99165 (F1000推薦)
11.Xiang, G., Yang, L., Long, Q., …Liu, X*.(2017). BNIP3L-dependent mitophagy accounts for mitochondrial clearance during 3 factors-induced somatic cell reprogramming.Autophagy, 13(9):1543-1555.
12.Zhou, Y., Long, Q., Wu, H., …Liu, X*. (2020). Topology-dependent, bifurcated mitochondrial quality control under starvation.Autophagy, 16(3):562-574. (封麵)
13.Wu, Y., Chen, K., Li L., …Liu, X*. (2022). Plin2-mediated lipid droplet mobilization accelerates exit from pluripotency by lipidomic remodeling and histone acetylation.Cell Death & Differentiation,29(11):2316-2331.
14.Xing, G., Liu, Z., Huang L., …Pei, D*Liu, X*& Chen, K*. (2022). MAP2K6 remodels chromatin and facilitates reprogramming by activating Gatad2b-phosphorylation dependent heterochromatin loosening.Cell Death & Differentiation,29(5):1042-1054.
15.Yang, L., Lin, X., Tang, H.,....Liu, X*. (2020).Mitochondrial DNA mutation exacerbates female reproductive aging via impairment of the NADH/NAD+redox.Aging Cell19(9):e13206.
16.Yao, D., Li, Y., Zeng, S.,…Liu, X*.(2022).Short-form OPA1 is a molecular chaperon in mitochondrial intermembrane space.Science China-Life Sciences,65(2):227-235.(封麵).
17.Bao, F., Shi, H., Gao, M.,…Liu, X*.(2018). Polybrene induces neural degeneration by bidirectional Ca2+influx dependent mitochondrial and ER-mitochondrial dynamics.Cell Death & Disease, 9(10):966.
18.Li, L., Chen, K., Wu Y.,...Liu, X*.(2017). Gadd45a opens up the promoter regions of miR-295 facilitating pluripotency induction.Cell Death & Disease, 8(10):e3107.
19.Lin, Y., Xiao, M., Chen, H., Meng, Y., Zhao, N., Yang, L., Tang, H., Wang, J.,Liu, X*, Zhu, Y.*, Zhuang, S.*. (2019). A novel mitochondrial micropeptide MPM enhances mitochondrial respiratory activity and promotes myogenic differentiation.Cell Death & Disease, 10(7):528
20.Yang, L., Long, Q., Liu, J., ...Liu, X*.(2015). Mitochondrial fusion provides an ‘initial metabolic complementation’ controlled by mtDNA.Cellular and Molecular Life Sciences,72(13):2585-2598.
21.Chen, K., Long, Q., Wang, T., …Liu, X*&Pei, D*. (2016). Gadd45a is a heterochromatin relaxer that enhances iPScellgeneration.EMBO Reports,17(11): 1641-1656.
22.Bao, F., Shi, H., Long, Q., …Liu, X*.(2016). Mitochondrial membrane potential-dependent endoplasmic reticulum fragmentation is an important step in neuritic degeneration.CNS Neuroscience & Therapeutics,22(8):648-660.(封麵)
23.Yang, L., Tang, H., Lin, X....Liu, X*. (2020). OPA1-Exon4b binds to mtDNA D-loop for transcriptional and metabolic modulation, independent of mitochondrial fusion.Frontiers in Cell and Developmental Biology,8: 180.
24.Wu, Y., Chen, K., Liu, X., ...Liu, X*.(2015). Srebp‐1 Interacts with c‐Myc to Enhance Somatic Cell Reprogramming.Stem Cells,34(1): 83-92.
25.Long, Q., Zhao, D., Fan, W., ...Wang X*&Liu, X*.(2015). Modeling of mitochondrial donut formation.Biophysical Journal, 109(5):892-899.
26.Liu, W., Long, Q., Chen, K., ... &Liu, X*.(2013). Mitochondrial metabolism transition cooperates with nuclear reprogramming during induced pluripotent stem cell generation.Biochemical and Biophysical Research Communications,431(4), 767-771.
27.Liu, X.,Weaver, D., Shirihai, O., & Hajnóczky, G. (2009). Mitochondrial ‘kiss‐and‐run’: interplay between mitochondrial motility and fusion–fission dynamics.The EMBO Journal, 28(20), 3074-3089.(F1000推薦)
28.Liu, X., & Hajnoczky, G. (2011). Altered fusion dynamics underlie unique morphological changes in mitochondria during hypoxia–reoxygenation stress.Cell Death & Differentiation, 18(10), 1561-1572.(F1000推薦)
29.Weaver, D., Eisner, V.,Liu, X., … & Hajnóczky, G. (2014). Distribution and apoptotic function of outer membrane proteins depend on mitochondrial fusion.Molecular Cell, 54(5), 870-878.(co-first author)