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專家人才

  • 姓名：鄭輝
  • 性別：男
  • 職稱：研究員
  • 學曆：博士
  • 電話：
  • 傳真：
  • 電子郵件:zheng_hui@gibh.ac.cn
  • 通訊地址廣州市開源大道190號

    簡曆：

  • 2001-2005清華大學生物科學與技術係學士學位

    2005-2010美國明尼蘇達大學藥理係博士學位

    2010-2010美國明尼蘇達大學藥理係博士後

    2010-至今betway体育下载 研究員

    研究領域：

  • 1.細胞命運轉換（分化，去分化，轉分化）的機製研究

    2.神經幹細胞介導的學習和記憶

    3 . 嗎啡受體的信號通路和成癮性研究

    承擔科研項目情況：

    社會任職：

    獲獎及榮譽：

    代表論著：

  • *代表通訊作者

    第一作者或者通訊作者論文

    01)Zheng H, Hutchins AP, Pan G, Li Y, Pei D*, & Pei G* Where cell fate conversions meet Chinese philosophy. Cell Res (2014) 24(10):1162-3.

    02) Li W, He S, Zhou Y, Li Y, Hao J, Zhou X, Wang F, Zhang Y, Huang Z, Li Z, Loh HH, Law PY, &Zheng H*Neurod1 Modulates Opioid Antinociceptive Tolerance via Two Distinct Mechanisms. Biol Psychiatry (2014) 76(10):775-84.

    03) Li X, Pei D, &Zheng H*Transitions between epithelial and mesenchymal states during cell fate conversions. Protein Cell (2014) 5(8):580-91.

    04) Liu X, Sun H, Qi J, Wang L, He S, Liu J, Feng C, Chen C, Li W, Guo Y, Qin D, Pan G, Chen J, Pei D*, &Zheng H*Sequential introduction of reprogramming factors reveals a time-sensitive requirement for individual factors and a sequential EMT-MET mechanism for optimal reprogramming. Nat Cell Biol (2013) 15(7):829-838.

    05)Zheng H*, Zhang Y, Li W, Loh HH, & Law PY NeuroD Modulates Opioid Agonist-Selective Regulation of Adult Neurogenesis and Contextual Memory Extinction. Neuropsychopharmacology (2013) 38(5):770-777.

    06)Zheng H*, Loh HH, & Law PY Posttranslation modification of G protein-coupled receptor in relationship to biased agonism. Methods Enzymol (2013) 522:391-408.

    07)Zheng H*, Zou H, Liu X, Chu J, Zhou Y, Loh HH, & Law PY Cholesterol level influences opioid signaling in cell models and analgesia in mice and humans. J Lipid Res (2012) 53(6):1153-1162.

    08)Zheng H*, Pearsall EA, Hurst DP, Zhang Y, Chu J, Zhou Y, Reggio PH, Loh HH, & Law PY Palmitoylation and membrane cholesterol stabilize mu-opioid receptor homodimerization and G protein coupling. BMC Cell Biol (2012) 13:6.

    09)Zheng H*, Law PY, & Loh HH Non-Coding RNAs Regulating Morphine Function: With Emphasis on the In vivo and In vitro Functions of miR-190. Front Genet (2012) 3:113.

    10)Zheng H*, Chu J, Zhang Y, Loh HH, & Law PY Modulating micro-opioid receptor phosphorylation switches agonist-dependent signaling as reflected in PKCepsilon activation and dendritic spine stability. J Biol Chem (2011) 286(14):12724-12733.

    11)Zheng H*, Zeng Y, Zhang X, Chu J, Loh HH, & Law PY mu-Opioid Receptor Agonists Differentially Regulate the Expression of miR-190 and NeuroD. Mol Pharmacol (2010) 77(1):102-109.

    12)Zheng H*, Zeng Y, Chu J, Kam AY, Loh HH, & Law PY Modulations of NeuroD activity contribute to the differential effects of morphine and fentanyl on dendritic spine stability. J Neurosci (2010) 30(24):8102-8110.

    13)Zheng H*, Loh HH, & Law PY Agonist-selective signaling of G protein-coupled receptor: Mechanisms and implications. IUBMB Life (2010) 62(2):112-119.

    14)Zheng H*, Chu J, Zeng Y, Loh HH, & Law PY Yin Yang 1 phosphorylation contributes to the differential effects of mu-opioid receptor agonists on microRNA-190 expression. J Biol Chem (2010) 285(29):21994-22002.

    15)Zheng H*, Loh HH, & Law PY beta-Arrestin-Dependent mu-Opioid Receptor-Activated Extracellular Signal-Regulated Kinases (ERKs) Translocate to Nucleus in Contrast to G Protein-Dependent ERK Activation. Mol Pharmacol (2008) 73(1):178-190.

    16)Zheng H*, Chu J, Qiu Y, Loh HH, & Law PY Agonist-selective signaling is determined by the receptor location within the membrane domains. Proc Natl Acad Sci U S A (2008) 105(27):9421-9426.

    其他論文

    01) Xu C*, Zhang Y,Zheng H, Loh HH, & Law PY Morphine modulates mouse hippocampal progenitor cell lineages by up-regulating miR-181a level. Stem Cells (2014) 32(11):2961-72.

    02) Wu Q*, Hwang CK,Zheng H, Wagley Y, Lin HY, Kim do K, Law PY, Loh HH, & Wei LN MicroRNA 339 down-regulates mu-opioid receptor at the post-transcriptional level in response to opioid treatment. FASEB J (2013) 27(2):522-535.

    03) Chu J*,Zheng H, Zhang Y, Loh HH, & Law PY Agonist-dependent mu-opioid receptor signaling can lead to heterologous desensitization. Cell Signal (2010) 22(4):684-696.

    04) Chu J*,Zheng H, Loh HH, & Law PY Morphine-induced mu-opioid receptor rapid desensitization is independent of receptor phosphorylation and beta-arrestins. Cell Signal (2008) 20(9):1616-1624.

    05) Pan G, Li J, Zhou Y,Zheng H, & Pei D* A negative feedback loop of transcription factors that controls stem cell pluripotency and self-renewal. FASEB J (2006) 20(10):1730-1732.

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