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專家人才

  • 姓名:秦寶明
  • 性別:
  • 職稱:研究員
  • 學曆:博士
  • 電話:
  • 傳真:
  • 電子郵件:qin_baoming@gibh.ac.cn
  • 通訊地址廣州市開源大道190號

    簡曆:

  • 教育:
    2007.9-2010.6,博士,細胞生物學,betway体育下载
    1994.9-1998.6,學士,生物化學與分子生物學,北京大學生命科學學院
    工作:
    2013.9-現在,研究員,中科院廣州生物醫藥與健康研究院
    2010.7-2013.8,副研究員,中科院廣州生物醫藥與健康研究院
    2004.9-2007.8,助理研究員,中科院廣州生物醫藥與健康研究院

    研究領域:

  • 代謝與細胞命運實驗室:

    衰老主要通路mTORC1-線粒體在幹細胞穩態維持和命運決定中的作用和機製;

    胚胎發育早期不同命運幹細胞的轉錄和表觀遺傳調控機理。

    承擔科研項目情況:

    社會任職:

    獲獎及榮譽:

  • 2019年,廣東省自然科學一等獎“尿液誘導多能幹細胞技術及體細胞重編程機製”(第二完成人);廣州開發區“黃埔人才”;

    2017,中國科學院傑出科技成就獎“幹細胞多能性與重編程機理研究集體”(主要完成人);

    2016,廣東省“特支計劃”科技創新領軍人才;

    2013,國家自然科學二等獎“幹細胞多能性與重編程機理研究”(第三完成人)。

    代表論著:

  • 1, Xueting Xu, …, Baoming Qin. (2021) The mTORC1-eIF4F axis controls paused pluripotency. EMBO Reports, e53081. DOI: 10.15252/embr.202153081.

    2, Yinghua Huang, Hui Zhang, …, Miguel A. Esteban*, Baoming Qin*. (2020) JMJD3 acts in tandem with KLF4 to facilitate reprogramming to pluripotency. Nature Communications, 11: 5061-5076. (*co-corresponding author)

    3, Zicong Liu, …, Gongcheng Hu*, Baoming Qin*. (2019) Generation of Rybp homozygous knockout murine ES cell line GIBHe001-A-1 by using CRISPR/Cas9 technology. Stem Cell Research, 41: 101638-101641. (*co-corresponding author)

    4, Lulu Wang, …, Baoming Qin. (2019) mTORC1-PGC1 axis regulates mitochondrial remodeling during reprogramming. The FEBS Journal, DOI: 10.1111/febs.15024.

    5, Yasong Wu, Yuan Li, …, Baoming Qin*, Duanqing Pei*. (2015) Autophagy and mTORC1 regulate the stochastic phase of somatic cell reprogramming. Nature Cell Biology, 17: 715-725. (*co-corresponding author)

    6, Xichen Bao, …, Baoming Qin*, Miguel Angel Esteban*. (2013) MicroRNAs in somatic cell reprogramming. Current Opinion in Cell Biology, 25: 208-214. (*co-corresponding author)

    7, Jianbin Su, …, Baoming Qin. (2013) Roles of small molecules in somatic cell reprogramming. Acta Pharmacologica Sinica, 34: 719-724.

    8, Miguel Angel Esteban#, Tao Wang#, Baoming Qin#, …, Duanqing Pei. (2010) Vitamin C enhances the generation of mouse and human induced pluripotent stem cells. Cell Stem Cell, 6 (1): 1-9. (#co-first author; cover story)

    9, Baoming Qin, …, Duanqing Pei. (2006) Sorting nexin 10 induces giant vacuoles in mammalian cells. Journal of Biological Chemistry, 281 (48): 36891-36896. (cover story)

    10, Baoming Qin, …, Duanqing Pei. (2005) Identification of EGFR kinase domain mutations among lung cancer patients in China: implication for targeted cancer therapy. Cell Research, 15 (3): 212-217.

    11, Ping Cui#, Baoming Qin#, …, Duanqing Pei. (2004) Nuclear localization of the phosphatidylserine receptor protein via multiple nuclear localization signals. Experimental Cell Research, 293: 154-163. (#co-first author)

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