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專家人才

  • 姓名：李尹雄
  • 性別：男
  • 職稱：研究員
  • 學曆：博士
  • 電話：
  • 傳真：
  • 電子郵件:li_yinxiong@gibh.ac.cn
  • 通訊地址廣州市科學城開源大道190號

    簡曆：

  • 1979-1985 中南大學湘雅醫學院 醫學學士
    1987-1991 協和醫科大學 醫學哲學博士
    1985-1987 中國醫學科學院基礎所助理研究員
    1991-1992 中國協和醫科大學助理教授
    1992-1993 Vanderbilt 大學醫學院細胞生物學 博士後
    1993-2001 Medical College of Georgia博士後
    2001-2010 Duke大學醫學院，終身製助教授
    2010-2011 南卡羅蘭拉醫科大學副教授
    2011-2012 首席技術官/副總裁 ，SMT 公司
    2012-今 betway体育下载 ，研究員，公共健康所所長
    國家科技重大專項 973 “幹細胞治療重大疾病機理研究” 首席科學家

    研究領域：

  • · 肝髒發育和成體肝髒幹細胞的分子調控機理研究；

    · 環境因素及酒精的先天致畸原理和預防研究；

    · 組織修複，纖維化及成體幹細胞功能的調控探討；

    · 人群中膽固醇狀況，Hedgehog信息通路與成體幹細胞健康和老化研究

    · 生物標誌物篩選和疾病基因診斷的研發

    承擔科研項目情況：

  • 1.Shaoyang Zhao, Jianhong Xia, Xiuhua Wu, Leilei Zhang, Pengtao Wang, Haiyun Wang, Heying Li, Xiaoshan Wang, Yan Chen, Jean Agnetti,Yinxiong Li, Duanqing Pei & Xiaodong Shu (2018) Deficiency in class III PI3-kinase confers postnatal lethality with IBD-like features in zebrafishNature Communications. 9, 2639
    2.Xu, G., Guo, D., Wu, F., Lai, K., Yuan, F., Liu, Y., Zhuang, Y., Wu, Y., Xu, Y., Chen, Y., Yang, F., You, K., Pan, T., Abbas, N. &Li, Y.-x. (2017) Generation of a GDE Heterozygous Mutation Human Embryonic Stem Cell Line WAe001-A-14 by CRISPR/Cas9 Editing,Stem Cell Research. 27:38-41.
    3.Yuan, F., Guo, D., Liu, Y., Xu, Y., Gao, G., Wu, Y., Yang, F., Ke, X., Lai, K., Wei, H. &Li, Y.-X.(2017) Generation of an ASS1 heterozygous knockout human embryonic stem cell line, WAe001-A-13, using CRISPR/Cas9,Stem Cell Research. 26:67-71.
    4.Wu, F., Gao, G., Pan, T., Yang, Z., Xu, G., Abbas, N., Liu, Y., Chen, Y., Tan, S., You, K., Ke, X., Zhuang, Y., Lin, X., Yang, F. &Li, Y.-x.(2017) Generation of a SMO Homozygous Knockout Human Embryonic Stem Cell Line WAe001-A-16 by CRISPR/Cas9 Editing,Stem Cell Research. 27:5-9
    5.Lin, M., Xue, X. Y., Liang, S. Z.,Li, Y. X., Lv, Y. Y., He, L. H., Xu, K. C., Zhang, L. F., Chen, J. B. & Niu, L. Z. (2017) MiR-187 overexpression inhibits cervical cancer progression by targeting HPV16 E6,Oncotarget.8, 62914-62926
    6.Yuan, F., Guo, D., Gao, G., Liu, Y., Xu, Y., Wu, Y., Yang, F., Ke, X., Lai, K. &Li, Y.-x.(2017) Generation of a KCNJ11 homozygous knockout human embryonic stem cell line WAe001-A-12 using CRISPR/Cas9,Stem Cell Research. 24, 89-93.
    7.Liu, Y., Wu, F., Zhuang, Y., Guo, D., Abbas, N., Wei, R., Wang, K., Chen, Y., Tao, J., Wu, Y., Yuan, F., Pan, T., Yang, F., Lai, K., Lai, L. &Li, Y.-x.(2017) Generation of three miR-122 knockout lines from a human embryonic stem cell line,Stem Cell Research.24, 164-168.
    8.Liu, Y., Ruzi, A., Guo, D., Wu, F., Liu, H., Wu, H., Wu, Y., Yuan, F., Zhuang, Y., Yang, F., Lai, K., Lai, L. &Li, Y.-x.(2017) Generation of two MEN1 knockout lines from a human embryonic stem cell line,Stem Cell Research. 24, 169-173.
    9.Liu, H., Guo, D., Ruzi, A., Chen, Y., Pan, T., Yang, F., Li, J., Xu, K., Zhou, T., Qin, D. &Li, Y. X.(2017) Testosterone improves the differentiation efficiency of insulin-producing cells from human induced pluripotent stem cells,PLoS One.12, e0179353.
    10.Xu, Y., Wu, Y., Guo, D., Gao, G., Lai, K., Yang, F., Wang, K., Wu, H., Lai, L., Li, J., Xu, K. &Li, Y.-x.(2017) Generation of an ASGR1 homozygous mutant human embryonic stem cell line WAe001-A-6 using CRISPR/Cas9,Stem Cell Research.22, 29-32.
    11.Li, Q., Hutchins, A. P., Chen, Y., Li, S., Shan, Y., Liao, B., Zheng, D., Shi, X.,Li, Y., Chan, W.-Y., Pan, G., Wei, S., Shu, X. & Pei, D. (2017) A sequential EMT-MET mechanism drives the differentiation of human embryonic stem cells towards hepatocytes,Nature Communications.8. 15166.
    12.Guo, D., Liu, H., Ruzi, A., Gao, G., Nasir, A., Liu, Y., Yang, F., Wu, F., Xu, G. &Li, Y.-x.(2017) Modeling Congenital Hyperinsulinism with ABCC8-Deficient Human Embryonic Stem Cells Generated by CRISPR/Cas9,Scientific Reports.7, 3156.
    13.Guo, D., Wu, F., Liu, H., Gao, G., Kou, S., Yang, F., Abbas, N., Zhou, T., Cai, X., Zhang, H., Qin, D., Li, J., Xu, K. &Li, Y.-x.(2017) Generation of non-integrated induced pluripotent stem cells from a 59-year-old female with multiple endocrine neoplasia type 1 syndrome,Stem Cell Research.18, 64-66.
    14.Guo, D., Liu, H., Gao, G., Liu, Y., Zhuang, Y., Yang, F., Wang, K., Zhou, T., Qin, D., Hong, L., Li, J., Xu, K. & Li,Y.-x.(2017) Creating a patient carried Men1 gene point mutation on wild type iPSCs locus mediated by CRISPR/Cas9 and ssODN,Stem Cell Research.18, 67-69.
    15.Guo, D., Wu, F., Liu, H., Gao, G., Kou, S., Yang, F., Abbas, N., Zhou, T., Cai, X., Zhang, H., Qin, D., Li, J., Xu, K. &Li, Y.-x.(2017) Generation of non-integrated induced pluripotent stem cells from a 23-year-old male with multiple endocrine neoplasia type 1 syndrome,Stem Cell Research.18, 70-72.
    16.Guo, D., Liu, H., Gao, G., Ruzi, A., Wang, K., Wu, H., Lai, K., Liu, Y., Yang, F., Lai, L. &Li, Y.-x.(2016) Generation of an Abcc8 homozygous mutation human embryonic stem cell line using CRISPR/Cas9,Stem Cell Research.17, 640-642.
    17.Guo, D., Liu, H., Gao, G., Ruzi, A., Wang, K., Wu, H., Lai, K., Liu, Y., Yang, F., Lai, L. &Li, Y.-x.(2016) Generation of an Abcc8 heterozygous mutation human embryonic stem cell line using CRISPR/Cas9,Stem Cell Research.17, 670-672.

    18.Li Y-X, Zdanowicz M, Young L, Kumiski D, Leatherbury L and Kirby ML. Cardiac neural crest in zebrafish embryos contributes to myocardial cell lineage and early heart functionDevelopment Dynamics. 226:540-550, 2003. PMID: 12619138

    19.Li Y-X, Kirby ML. Coordinated and conserved expression of alphoid repeat and alphoid repeat-tagged coding sequences.Developmental Dynamics228(1):72-81, 2003. PMID: 12619138

    20.Wilkbanks AM, Fralish GB, Kirby ML, Barak LS,Li Y-X*and Caron MG.* Arrestin 2 regulates zebrafish development through the sonic hedgehog pathway.Science.306:2264-2267, 2004. (*co-correspondence authors). PMID: 15618520

    21.Li YX*, Yang HT, Danowicz M, Sicklick JK, Qi Y, Camp T and Diehl AM. Fetal Alcohol Exposure Impairs Hedgehog Cholesterol Modification and Signaling.Lab Invest. 87(3):231-40. 2007. (Presented as the Journal cover picture and with an Editorial Press Release) (* correspondence authors). PMID: 17237799.

    22.Yang L, Wang Y, Mao H, Fleig S, Omenetti A, Brown KD, Sicklick JK,Li YX, Diehl AM. Sonic hedgehog is an autocrine viability factor for myofibroblastic hepatic stellate cells.Journal of Hepatology48:98-106. 2008. PMID: 1802272. PMC2196213.

    23.Hua Mao H., Diehl AM.,Li YX. Sonic Hedgehog Ligand Partners with Caveolin-1 for Intracellular Transportation.Lab Invest. 89:290-300. 2009. PMID: 19139721. PMC2647995

    社會任職：

    獲獎及榮譽：

  • · 1991 歐洲分子生物學訓練班學生獎，聯合國世界科教文組織

    · 1992美國衛生部國立衛生研究院 國際中心 博士後研究Forgarty獎

    · 1996中國國家科學技術進步二等獎，衛生部，獎號：96202303

    · 1996中國國家最佳教育科技出版獎，教育部

    · 1999外藉最傑出科學教育人士，美國新聞總署 國家移民規劃局

    · 2005 杜克-斯特曼腫瘤及幹細胞研究獎，杜克大學

    ·2004-2008美國心髒協會科研基金分子生物學和細胞生物學審批，主評委員

    ·2009美國國立衛生院（NIH）肝髒幹細胞總統科學促進計劃基金，Challenge Grant Panel 18 (ZRG1 DKUS A58, Liver stem cell study) 科學審批委員會委員

    ·2010美國國立衛生院(NIH)先天畸形及酒精致畸國家科研基金，Special Emphasis Panel (ZAA1DD 01, Alcohol Defect research center grant) 科學審批委員會委員

    代表論著：

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