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專家人才

  • 姓名：姚紅傑
  • 性別：男
  • 職稱：研究員
  • 學曆：博士
  • 電話：020-32015279
  • 傳真：
  • 電子郵件:yao_hongjie@@gibh.ac.cn
  • 通訊地址廣州市科學城開源大道190號

    簡曆：

  • 姚紅傑，博士，研究員，健康研究中心主任，國家傑出青年科學基金獲得者，國家重點研發計劃項目負責人。2005年畢業於中國科學院植物研究所，獲理學博士學位。從2005年11月出國留學，先後在美國賓夕法尼亞州立大學、美國國立衛生研究院等機構從事博士後研究工作，主要從事表觀遺傳及染色質組織對基因表達調控的機理研究。2011年10月加入betway体育下载 ，建立“幹細胞表觀遺傳調控”研究組，任課題組長、研究員、博士生導師。2012年獲得中科院人才計劃擇優支持（終期評估優秀）。作為課題負責人先後承擔來自國家自然科學基金、國家重點研發計劃、中科院戰略性先導科技專項、廣東省重點領域研發計劃項目的資助；參加科技部幹細胞重大科學研究計劃（973）項目。近年來，相關研究成果以通訊作者分別發表在Cell Stem Cell, Science Advances, Nature Communications, Nucleic Acids Research, Cell Reports等學術刊物上。

    研究領域：

  • 1）幹細胞命運調控的表觀遺傳機製

    2）人類疾病的幹細胞模型、動物模型的建立和致病機製研究

    3）腫瘤發生發展的表觀 遺傳調控機製

    承擔科研項目情況：

  • 國家傑出青年科學基金項目

    國家科技部重點研發計劃

    國家自然科學基金聯合基金重點項目

    中科院器官重建與製造先導專項

    廣東省重點領域研發計劃項目

    社會任職：

  • 中國生物化學與分子生物學學會基因專業委員會委員

    中國生物化學與分子生物學學會核糖核酸專業委員會委員

    中國生物物理學會衰老生物學分會委員

    Scientific Reports,編委

    獲獎及榮譽：

  • 2021國家重點研發計劃首席科學家

    2021廣州市黃埔區傑出人才

    2020臻溪生命科學優秀教育工作者

    2019國家傑出青年科學基金獲得者

    2018中國科學院廣州教育基地“優秀研究生導師”

    2017中國科學院院級人才計劃終期評估優秀

    2016中國科學院廣州分院“優秀青年科學家”

    2012中國科學院院級人才計劃入選者

    2010美國國立衛生研究院“研究員卓越研究獎”

    2004中國科學院院長獎學金優秀獎

    2001山西省“興晉挑戰杯”高校青年師生學術科技作品競賽優秀獎

    代表論著：

  • 1)Dong X, Guo R, Ji T, Zhang J, Xu J, Li Y, Sheng Y, Wang Y, Fang K, Wen Y, Liu B, Hu G, Deng H,Yao H*. YY1 safeguard multidimensional epigenetic landscape associated with extended pluripotency.Nucleic Acids Research2022. Apr 15: gkac230. doi: 10.1093/nar/gkac230. (Breakthrough Article)

    2)Song Y, Liang Z, Zhang J, Hu G, Wang J, Li Y, Guo R, Dong X, Babarinde IA, Ping W, Sheng YL, Li H, Chen Z, Gao M, Chen Y, Shan G, Zhang MQ, Shan G, Hutchins AP, Fu X-D*,Yao H*. CTCF functions as an insulator for somatic genes and a chromatin remodeler for pluripotency genes during reprogramming.Cell Reports2022. Apr 5;39(1):110626.

    3)Hu G, Dong X, Gong S, Song Y, Hutchins AP,Yao H*. Systematic screening of CTCF binding partners identifies that BHLHE40 regulates CTCF genome-wide distribution and long-range chromatin interactions.Nucleic Acids Research2020. 48(17): 9606-9620.

    4)Li Y, Song Y, Xu W, Li Q, Wang X, Li K,Wang J, Liu Z, Velychko S, Ye R, Xia Q, Wang L, Guo R, Dong X, Zheng Z, Dai Y, Li H, Yao M, Xue Y, Scho？ler HR, Sun Q*,Yao H*. R-Loops Coordinate with SOX2 in Regulating Reprogramming to Pluripotency.Science Advances2020. 6(24): eaba0777.

    5)Li J, Huang K, Hu G, Babarinde IA, Li Y, Dong X, Chen Y-S, Shang L, Guo W, Wang J, Chen Z, Hutchins AP, Yang Y-G,Yao H*. An Alternative CTCF Isoform Antagonizes Canonical CTCF Occupancy and Changes Chromatin Architecture to Promote Apoptosis.Nature Communications2019. 10(1): 1535. doi.org/10.1038/s41467-019-08949-w. (Highlighted by Nature Communications Editor).

    6)Yao M, Zhou X, Zhou J, Gong S, Hu G, Li J, Huang K, Lai P, Shi G, Sun H, Wang H,Yao H*.PCGF5 is Required for Neural Differentiation of Embryonic Stem Cells.Nature Communications2018. 9(1):1463. doi: 10.1038/s41467-018-03781-0.

    7)Li H, Lai P, Jia J, Song Y, Xia Q, Huang K, He N, Ping W, Chen J, Yang Z, Li J, Yao M, Dong X, Zhao J, Hou C, Esteban MA, Gao S, Pei D, Hutchins AP,Yao H*. RNA Helicase DDX5 Inhibits Reprogramming to Pluripotency by miRNA-based Repression of RYBP and its PRC1-dependent and -independent Functions.Cell Stem Cell2017. 20(4):462-477. (Previewed by Cell Stem Cell).

    8)Li W, Shang L, Huang K, Li J, Wang Z,Yao H*. Identification of Critical Base Pairs Required for CTCF Binding in Motif M1 and M2.Protein & Cell2017. 8: 544-549.

    9)Xia Q, Cui G, Fan Y, Wang X, Hu G, Wang L, Luo X, Yang L, Cai Q, Xu K, Guo W, Gao M, Li Y, Wu J, Li W, Chen J, Qi H, Peng G*,Yao H*. RNA helicase DDX5 acts as a critical regulator for survival of neonatal mouse gonocytes.Cell Proliferation2021 Mar 5:e13000. doi: 10.1111/cpr.13000.

    10)Song Y, Hu G, Jia J, Yao M, Wang X, Lu W, Hutchins AP, Chen J, Ozato K,Yao H*. DNA Damage Induces Dynamic Associations of BRD4/P-TEFb With Chromatin and Modulates Gene Transcription in a BRD4-Dependent and -Independent Manner.Front Mol Biosci.2020. 7: 618088.

    11)Ping W, Hu J, Hu G, Li H, Song Y, Xia Q, Yao M, Gong S, Jiang C*,Yao H*. Genome-wide DNA Methylation Analysis Reveals that Mouse Chemical iPSCs Have Closer Epigenetic Features to mESCs than OSKM-integrated-iPSCs.Cell Death & Disease2018. 9(2):187.

    12)Shan Y, Liang Z, Xing Q, Zhang T, Wang B, Tian S, Huang W, Zhang Y, Yao J, Zhu Y, Huang K, Liu Y, Wang X, Chen Q, Zhang J, Shang B, Li S, Shi X, Liao B, Zhang C, Lai K, Zhong X, Shu X, Wang J,Yao H, Chen J, Pei D, Pan G*. PRC2 specifies ectoderm lineages and maintains pluripotency in primed but not na？ve ESCs.Nature Communications2017. 8(1):672. doi: 10.1038/s41467-017-00668-4.

    13)Peng X, So KK, He L, Zhao Y, Zhou J, Li Y, Yao M, Xu B, Zhang S,Yao H, Hu P, Sun H*, Wang H*. MyoD and FoxO3 mediated hotspot interaction orchestrates super-enhancer activity during myogenic differentiation.Nucleic Acids Research2017. 45: 8785-8805.

    14)Huang K, Zhang X, Shi J, Yao M, Lin J, Li J, Liu H, Li H, Shi G, Wang Z, Zhang B, Chen J, Pan G, Jiang C, Pei D*,Yao H*.Dynamically Reorganized Chromatin is the Key for the Reprogramming of Somatic Cells to Pluripotent Cells.Scientific Reports2015. 5:17691. doi: 10.1038/srep17691.

    15)Liu J, Han Q, Peng T, Peng M, Wei B, Li D, Wang X, Yu S, Yang J, Cao S, Huang K, Hutchins AP, Liu H, Kuang J, Zhou Z, Chen J, Wu H, Guo L, Chen Y, Chen Y, Li X, Wu H, Liao B, He W, Song H,Yao H, Pan G, Chen J*, Pei D*. The Oncogene c-Jun Impedes Somatic Cell Reprogramming.Nature Cell Biology2015. 17:856-67.

    16)Liu L, Xu Y, He M, Zhang M, Cui F, Lu L, Yao M, Tian W, Benda C, Zhuang Q, Huang Z, Li W, Li X, Zhao P, Fan W, Luo Z, Li Y, Wu Y, Hutchins AP, Wang D, Tse HF, Schambach A, Frampton J, Qin B, Bao X,Yao H, Zhang B, Sun H, Pei D, Wang H, Wang J, Esteban MA*. Transcriptional Pause Release is a Rate-limiting Step for Somatic Cell Reprogramming.Cell Stem Cell2014. 15: 574-588.

    17)Huang K, Jia J, Wu C, Yao M, Li M, Jin J, Jiang C, Cai Y, Pei D, Pan G*,Yao H*. Ribosomal RNA Gene Transcription Mediated by the Master Genome Regulator Protein CCCTC-binding factor (CTCF) is Negatively Regulated by the Condensin Complex.Journal of Biological Chemistry2013. 288: 26067-26077.

    18)Chen J, Guo L, Zhang L, Wu H, Yang J, Liu H, Wang X, Hu X, Gu T, Zhou Z, Liu J, Liu J, Wu H, Mao S, Mo K, Li Y, Lai K, Qi J,Yao H, Pan G, Xu GL*, Pei D*. Vitamin C Modulates TET1 Function during Somatic Cell Reprogramming.Nature Genetics2013. 45:1504-1509.

    19)Hu J＃,Yao H＃, Gan F, Tokarski A, Wang Y*. Interaction of OKL38 and p53 in Regulating Mitochondrial Structure and Function.PLoS One2012. 7: e43362. (＃Equal contribution).

    20)Pan G, Wang T,Yao H, Pei D*. Somatic Cell Reprogramming for Regenerative Medicine: SCNT vs. iPS Cells.Bioessays2012. 34: 472-476.

    21)Ghirlando R, Giles K, Gowher H, Xiao T, Xu Z,Yao H, Felsenfeld G*. Chromatin Domains, Insulators, and the Regulation of Gene Expression.Biochim Biophys Acta2012. 1819: 644-651.

    22)Yao H, Brick K, Evrard Y, Xiao T, Camerini-Otero R, Felsenfeld G*. Mediation of CTCF Transcriptional Insulation by DEAD-box RNA-binding Protein p68 and Steroid Receptor RNA Activator SRA.Genes & Development2010. 24: 2543-2555.

    23)Li P, Wang D,Yao H, Doret P, Hao G, Shen Q, Qiu H, Zhang X, Wang Y, Chen G, Wang Y*. Coordination of PAD4 and HDAC2 in the Regulation of p53-target Gene Expression.Oncogene2010. 29: 3153-3162.

    24)Yao H, Li P, Venters B, Zheng S, Thompson P, Pugh BF, Wang Y*. Histone Arg Modifications and p53 Regulate the Expression of OKL38, a Mediator of Apoptosis.Journal of Biological Chemistry2008. 283: 20060-20068.

    25)Mochizuki K, Nishiyama A, Jang MK, Dey A, Ghosh A, Tamura T, Natsume H,Yao H, Ozato K*. The Bromodomain Protein Brd4 Stimulates G1 Gene Transcription and Promotes Progression to S Phase.Journal of Biological Chemistry2008. 283: 9040-9048.

    26)Tian S*,Yao H, Deng X, Xu X, Qin G, Chan Z. Characterization and Expression of beta-1, 3-Glucanase Genes in Jujube Fruit Induced by the Microbial Biocontrol AgentCryptococcus laurentii.Phytopathology2007. 97: 260-268.

    27)Yao H, Tian S*. Effects of a Biocontrol Agent and Methyl Jasmonate on Postharvest Diseases of Peach Fruit and the Possible Mechanisms Involved.Journal of Applied Microbiology2005. 98: 941-950.

    28)Yao H, Tian S*. Effects of Pre- and Postharvest Application of Salicylic Acid or Methyl Jasmonate on Inducing Disease Resistance of Sweet Cherry Fruit in Storage.Postharvest Biology and Technology2005. 35: 253-262.

    29)Yao H, Tian S*. Wang Y. Sodium Bicarbonate Enhances Biocontrol Efficacy of Yeasts on Fungal Spoilage of Pears.International Journal of Food Microbiology2004. 93: 297-304.
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