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專家人才

  • 姓名：王金勇
  • 性別：男
  • 職稱：研究員
  • 學曆：博士
  • 電話：
  • 傳真：
  • 電子郵件:wang_jinyong(AT)gibh.ac.cn
  • 通訊地址廣州市科學城開源大道190號

    簡曆：

  • 課題組簡介

    王金勇，研究員，血液與免疫細胞再生研究組組長，國家自然科學基金傑出青年科學基金（2019醫學部）獲得者，中國科學院大學博士生導師。他的研究團隊旨在結合體內誘導譜係重編程、體外誘導幹細胞分化、造血骨髓微環境原位重建等多途徑探索血液及免疫細胞再生與生理功能重建。其研究團隊長期聚焦“抗白血病免疫細胞再生與白血病骨髓微環境原位修複”研究，在T細胞再生等領域取得一係列原創技術突破，擁有多項發明專利

    個人經曆

    2012年3月至今：betway体育下载 ，研究員

    2007年9月-2012年2月：美國威斯康星醫學院、威斯康星大學麥迪遜醫學與公共衛生學院，博士後

    2006年8月-2007年8月：中國農業科學院上海獸醫研究所， 博士後

    2001年-2006年：浙江大學， 博士

    1997年-2001年：萊陽農學院，學士

    研究領域：

  • 血液與免疫細胞再生

    承擔科研項目情況：

    社會任職：

    獲獎及榮譽：

  • 獲國家傑出青年科學基金資助

    國家重點研發計劃項目首席科學家

    代表論著：

  • 1. Wang, T., Xia, C., Weng, Q., Wang, K., Dong, Y., Hao, S., Dong, F., Liu, X., Liu, L., Geng, Y., Guan, Y., Du, J., Cheng, T., Cheng, H.,Wang, J.Loss of Nupr1 promotes engraftment by tuning the quiescence threshold of hematopoietic stem cell repository via regulating p53-checkpoint pathway.Haematologica, DOI: 10.3324/haematol.2019.239186.

    2. Wang, T., Lv, C., Hu, F., Liu, L.,Wang, J.(2020) Two-step protocol for regeneration of immunocompetent T cells from mouse pluripotent stem cells.Blood Science2,79-88.

    3. Guo, R., Wu, H., Du, J.,Wang, J.(2020) T cell regeneration: an update on progress and challenges.Blood Science2, 22-26.

    4. Hu, F., Huang, D., Luo, Y., Zhou, P., LV, C., Wang, K., Weng, Q., Liu, X., Guan Y., Geng, Y., Du, J., Chen J.,Wang, J., and Wu, H. (2020) Haematopoietic lineage-converted T cells carrying tumour associated antigen-recognizing TCRs effectively kill tumour cells.Journal for ImmunoTherapy of Cancer, DOI: 10.1136/jitc-2019-000498.

    5. LV, C., Chen, S., Hu, F., Huang, D., Wang, T., Du, J.,Wang, J., and Wu, H. (2020) Pluripotent stem cell-derived CD19-CAR iT cells effectively eradicate B-cell lymphoma in vivo.Cellular & Molecular Immunology, DOI: 10.1038/s41423-020-0429-4.

    6. Xia, C., Wang, T., Cheng, H., Dong, Y., Weng, Q., Sun, G., Zhou, P., Wang, K., Liu, X., Geng, Y., Ma, S., Hao, S., Xu, L., Guan, Y., Du, J., Du, X., Li, Y., Zhu, X., Shi, Y., Xu, S., Wang, D., Cheng, T., andWang, J.(2020) Mesenchymal stem cells suppress leukemia via macrophage-mediated functional restoration of bone marrow microenvironment.Leukemia,34(9):2375-2383.

    7. Guo, R., Hu, F., Weng, Q., Lv, C., Wu, H., Liu, L., Li, Z., Zeng, Y., Bai, Z., Zhang, M., Liu, Y., Liu, X., Xia, C., Wang, T., Zhou, P., Wang, K., Dong, Y., Luo, Y., Zhang, X., Guan, Y., Geng, Y., Du, J., Li, Y., Lan, Y., Chen, J., Liu, B., andWang, J.(2020) Guiding T lymphopoiesis from pluripotent stem cells by defined transcription factors.Cell Research30, 21-33.

    8. Weng, Q., Hu, F., Zhang, M., Dong, Y., Lv, C., Wang, Y., Liu, X.,Wang, J.(2018) A protocol for generating induced T cells by reprogramming B cells in vivo.Cell Regeneration7, 7-15.

    9. Zhang, M., Dong, Y., Hu, F., Yang, D., Zhao, Q., Lv, C., Wang, Y., Xia, C., Weng, Q., Liu, X., Li, C., Zhou, P., Wang, T., Guan, Y., Guo, R., Liu, L., Geng, Y., Wu, H., Du, J., Hu, Z., Xu, S., Chen, J., He, A., Liu, B., Wang, D., Yang, Y. G., andWang, J.(2018) Transcription factor Hoxb5 reprograms B cells into functional T lymphocytes.Nat Immunology19, 279-290.

    10. Li, X., Xia, C., Wang, T., Liu, L., Zhao, Q., Yang, D., Hu, F., Zhang, M., Huang, K., Geng, Y., Zheng, Y., Guan, Y., Wu, H., Chen, X., Pan, G., Chen, J., Du, J., andWang, J.(2017) Pyrimidoindole derivative UM171 enhances derivation of hematopoietic progenitor cells from human pluripotent stem cells.Stem Cell Research21, 32-39.

    11. Chen, X., Zhao, Q., Li, C., Geng, Y., Huang, K., Zhang, J., Wang, X., Yang, J., Wang, T., Xia, C., Liu, X., Meng, M., Yang, D., Zheng, Y., Du, J., Zhang, X., Chen, J., Pan, G., andWang, J.(2015) OP9-Lhx2 stromal cells facilitate derivation of hematopoietic progenitors both in vitro and in vivo.Stem Cell Research15, 395-402.

    12. Yang, D., Zhang, X., Dong, Y., Liu, X., Wang, T., Wang, X., Geng, Y., Fang, S., Zheng, Y., Chen, X., Chen, J., Pan, G., andWang, J.(2015) Enforced expression of Hoxa5 in haematopoietic stem cells leads to aberrant erythropoiesis in vivo.Cell Cycle14, 612-620.

    13. Wang, T., Li, C., Xia, C., Dong, Y., Yang, D., Geng, Y., Cai, J., Zhang, J., Zhang, X., andWang, J.(2015) Oncogenic NRAS hyper-activates multiple pathways in human cord blood stem/progenitor cells and promotes myelomonocytic proliferation in vivo.Am J Transl Res7, 1963-1973.

    14.Wang, J., Kong, G., Liu, Y., Du, J., Chang, Y. I., Tey, S. R., Zhang, X., Ranheim, E. A., Saba-El-Leil, M. K., Meloche, S., Damnernsawad, A., Zhang, J., and Zhang, J. (2013) Nras(G12D/+) promotes leukemogenesis by aberrantly regulating hematopoietic stem cell functions.Blood121, 5203-5207.

    15.Wang, J., Liu, Y., Li, Z., Wang, Z., Tan, L. X., Ryu, M. J., Meline, B., Du, J., Young, K. H., Ranheim, E., Chang, Q., and Zhang, J. (2011) Endogenous oncogenic Nras mutation initiates hematopoietic malignancies in a dose- and cell type-dependent manner.Blood118, 368-379.

    16.Wang, J., Liu, Y., Li, Z., Du, J., Ryu, M. J., Taylor, P. R., Fleming, M. D., Young, K. H., Pitot, H., and Zhang, J. (2010) Endogenous oncogenic Nras mutation promotes aberrant GM-CSF signaling in granulocytic/monocytic precursors in a murine model of chronic myelomonocytic leukemia.Blood116, 5991-6002.

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