專家人才
- 姓名:Alexander Strunnikov
- 性別:男
- 職稱:研究員
- 學曆:博士
- 電話:
- 傳真:
- 電子郵件:alex@gibh.org
- 通訊地址廣州市科學城開源大道190號
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2009-至今:美國國家衛生研究院過敏和傳染病研究所免疫病理學實驗室 高級科學家
1996-2008:美國國家衛生研究院基因調控與發育實驗室 研究員
1992-1996: 華盛頓卡內基研究所胚胎係D. Koshland博士實驗室 博士後
1989-1991:俄羅斯科學院細胞研究所V. Larionov博士有絲分裂基因學實驗室研究生
1989:BioTechnika Ltd. 和 匈牙利生物研究中心 訪問學者
1987-1988:俄羅斯科學院細胞研究所染色體穩定與細胞工程實驗室 研究實習員
1985-1986:聖彼得堡流感研究所生物技術研究中心 基因工程係 實習和技術員
2009-至今:攻讀馬裏蘭州大學生物技術和生物信息學碩士 (非全日製,2012年畢業)
2010-2011:美國癌症研究所癌症研究中心“臨床腫瘤學轉化研究”繼續教育課程(兩個學期)
2008-2009:美國衛生研究所非學位課程:逆轉錄酶病毒,動物實驗操作程序,芯片技術,高通量篩選數據分析,Unix原理,高級SAS, 平行計算及其他。
1995: Cold Spring Harbor 實驗室課程:蛋白純化與特征
1987-1991:俄羅斯科學院細胞研究所博士學位
導師:Dr. V. Larionov.
論文題目:控製染色體在有絲分裂中分布的相關基因研究
1979-1984: 聖彼得堡大學生物與遺傳學學士學位(優秀)
主修:生物學和遺傳學, 兼修:生物教學
簡曆:
研究領域:
承擔科研項目情況:
社會任職:
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1999:提名為美國衛生研究院院長發言人之一
2001:霍德休斯醫學研究所導師資格
2006:為美國政府服務十年榮譽證書
職業協會會員資格:
美國遺傳協會
美國生物細胞協會
美國科學促進會
參加的項目評審小組:
2005: 美國國家衛生研究院細胞核動態和運輸特別研究小組
美國國家科學基金會
瑞士國家科學基金會
奧地利Fonds zur Forderung der Wisscenschaftlishen Forsung,
意大利癌症研究協會
英國國際癌症研究協會
英國威康信托基金會
新加坡科學技術研究會
新加坡生物醫藥研究理事會
新西蘭皇家馬斯登基金會
參加的演講與學術報告
應邀在美國國內及國際會議和學術報告會上多次發表演講:
1994年 美國舊金山細胞生物學學會年度會議
1995年 新墨西哥州陶斯細胞周期國際會議
1997年 新墨西哥州聖達菲細胞核組織和功能會議
1999年 美國國家衛生研究院學術報告演講人
2000年 費城美國人類遺傳學會第50屆會議
2000年 美國實驗生物學聯合會舉辦的關於染色體組織和複製會議
2002年 馬爾堡大學學術報告會
2002年 英國醫學研究理事會學術報告會
2002年 法國巴斯德研究院學術報告會
2005年 日本岡崎機製擴大國際會議
2005年 荷蘭奈梅亨分子科學中心學術報告會
2005年 美國吉斯通DNA複製會議
2007年 日本靜岡市細胞周期國際會議
2007年 日本東京科技學院學術報告會
2008年 西班牙巴塞羅那癌症預測和個體化醫學中心國際研討會
2009年 日本衝繩理工學院學術報告會
2010年 西班牙發展生物學安達盧西亞中心學術報告會
獲獎及榮譽:
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* E. Pugacheva, T. Suzuki, S. Pack, N. Kosaka-Suzuki, J. Yoon, A. Vostrov, E. Barsov,A.Strunnikov, H. Morse III, D. Loukinov, V. Lobanenkov. (2010) The structural complexity of thehumanBORISgene in gametogenesis and cancer.PLoS ONE5:e13872
* A. Samoshkin, A. Arnaoutov, L.E.T. Jansen, I. Ouispenski, L. Dye, T. Karpova, J. McNally, M.Dasso, Don W. Cleveland andA. Strunnikov.(2009) Human condensin function is essential for centromeric chromatin assembly and sister kinetochore orientation.PLoS ONE4:e6831
* S. Dulev, C. de Renty, R. Mehta, I. Minkov, E. Schwob andA. Strunnikov. (2009) Essential global role ofCDC14in DNA synthesis revealed by chromosome underreplication unrecognized by checkpoints incdc14mutants.PNAS106: 14466-14471
* Y. Takahashi, S. Dulev, X. Liu, N. Hiller, X. Zhao andA. Strunnikov(2008) Cooperation of sumoylated chromosomal proteins in rDNA maintenance.PLoS Genetics4:e1000215
* S. Dulev, L. Aragon, andA Strunnikov(2008) Unreplicated DNA in mitosis precludes condensin binding and chromosome condensation inS. cerevisae.Frontiers in Biosciences13:5838-5846
* Y. Takahashi andA. Strunnikov(2008)In vivomodeling of polysumoylation uncovers targeting of Topoisomerase II to the nucleolus via optimal level of SUMO modification.Chromosoma117:189-198
*B.D. Wang andA. Strunnikov(2008) Transcriptional homogenization of rDNA repeats in the episome-based nucleolus induces genome-wide changes in the chromosomal distribution of condensin.Plasmid59:45-53
*V. Yong-Gonzalez, B.D. Wang, P. Butylin, I. Ouspenski andA. Strunnikov(2007) Condensin function at centromere chromatin facilitates proper kinetochore tension and ensures correct mitotic segregation of sister chromatids.Genes to Cells12:1075-1090
*B. D. Wang, P. Butylin andA. Strunnikov(2006) Condensin function in mitotic nucleolar segregation is regulated by rDNA transcription.Cell Cycle5:2260-2267
*Y. Takahashi, V. Yong-Gonzalez, Y. Kikuchi andA. Strunnikov(2006) TheSIZ1/SIZ2control of chromosome transmission fidelity is mediated by their role in sumoylation of topoisomerase II.Genetics172:783-794
*B. Quimby, V. Yong-Gonzalez, T. Anan,A. Strunnikovand M. Dasso (2006) The
promyelocytic leukemia protein (PML) stimulates Sumo conjugation in yeast.Oncogene25:2999-3005
*B.D. Wang, D. Eyre, M. Basrai, M. Lichten andA. Strunnikov(2005) Condensin binding at distinct and specific chromosomal sites in theSaccharomyces cerevisiaegenome.Molecular andCellular Biology25: 7216-7225
*B. D. Wang, V. Yong-Gonzalez andA. Strunnikov. (2004) Cdc14p/FEAR pathway controls segregation of nucleolus inS. cerevisiaeby facilitating condensin targeting to rDNA chromatin in anaphase.Cell Cycle3:960-967
* A. Kagansky, L. Freeman, D. Lukyanov, andA. Strunnikov. (2004) Histone-tail independent chromatin-binding activity of recombinant cohesin holocomplex.Journal of BiologicalChemistry279:3382-3388
*J. Mascarenhas, J. Soppa ,A. Strunnikovand P. L. Graumann (2002) Cell cycle dependent localization of two novel prokaryotic chromosome segregation and condensation proteins inBacillus subtilisthat interact with SMC protein.EMBO Journal. 21:3108-3128
* A. Strunnikov, L. Aravind and E. V. Koonin (2001)Saccharomyces cerevisiae SMT4encodes an evolutionarily conserved protease with a role in chromosome condensation regulation.Genetics.158: 95- 107
*L. Aragon-Alcaide andA. Strunnikov(2000) Functional dissection ofin-vivointerchromosome association inS. cerevisiae.Nature Cell Biology2: 812-818
* L. Freeman, L.Aragon-Alcaide andA. Strunnikov(2000) The condensin complex governs chromosome condensation and mitotic transmission of rDNA.Journal of Cell Biology149: 811-824
*N. Darwiche, L. A. Freeman , andA. Strunnikov(1999) Characterization of the components of the putative mammalian sister chromatid cohesion complex.Gene. 233:39-47
*P. L. Graumann, R. Losick,A. V. Strunnikov(1998) Subcellular localization ofBacillus subtilisSMC, a protein involved in chromosome condensation and segregation.Journal of Bacteriology180:5749-5755
* V. Guacci, D. Koshland,A.V. Strunnikov(1997) A direct link between sister chromatid cohesion and chromosome condensation revealed through the analysis ofMCD1inS.cerevisiae.Cell91:47-57
A. Strunnikov, E. Hogan and D. Koshland (1995)SMC2, aSaccharomyces cerevisiaegene essential for chromosome segregation and condensation defines a subgroup within the SMCfamily.Genes and Development9: 87-599
A. Strunnikov, J. Kingsbury and D. Koshland (1995)CEP3encodes a centromere protein ofSaccharomyces cerevisiae.Journal of Cell Biology128:749-760
A. Strunnikov, V. Larionov and D. Koshland (1993)SMC1: an essential yeast gene encoding a putative head-rod-tail protein is required for nuclear division and defines a new ubiquitous protein family.Journal of Cell Biology123:1635-1648
V. Guacci, A. Yamamoto,A. Strunnikov, J. Kingsbury, E. Hogan, P. Meluh and D. Koshland (1993) Structure and function of chromosomes in mitosis of budding yeast. In:Cold SpringHarbor Symposia on Quantitative Biology/DNA and Chromosomes. 58:677-685, Cold Spring Harbor, New York
V. Larionov, N. Kouprina N.,A. Strunnikovand A. Vlasov (1989) A direct selection procedure for isolating yeast mutants with an impaired segregation of artificial minichromosomes.CurrentGenetics15:17-26
V. Larionov, N. Kouprina,A. Strunnikov, A. Vlasov and V. Pirozhkov (1989) Direct selection procedure for isolation of yeast mutants with impaired segregation of chromosomes.Progress inClinical and Biological Research, Vol. 138: Mechanisms of chromosome distribution and aneuploidy, 303-316; Alan R. Liss, Inc., New York
評論和圖書章節
* A. Strunnikov(2010) One-hit wonders of genomic instability.Cell Division5: 15
*Y. Takahashi, Iwase M,A. Strunnikov, Y. Kikuchi (2008) Cytoplasmic sumoylation by PIAStype Siz1-SUMO ligase. Cell Cycle. 7:1738-1744
* A. Strunnikov(2006) SMC complexes in bacterial chromosome condensation and segregation.Plasmid55:135-144
* A. Strunnikov. (2005) A case of selfish nucleolar segregation.Cell Cycle4: 113-117
* A. Strunnikov. (2003) Condensin and biological role of chromosome condensation.Progress in Cell Cycle Research5: 361-368
*P. Meluh andA. V. Strunnikov(2002) Beyond the ABC of CKC and SCC. Do centromeres orchestrate sister chromatid cohesion or vice versa?European Journal of Biochemistry. 269:2300–2314
* A. V. Strunnikov, R. Jessberger (1999) SMC Proteins: Conserved molecular properties for multiple biological functions.European Journal of Biochemistry. 263:6-13
* A. V. Strunnikov(1998) SMC proteins and chromosome structure.Trends in Cell Biology. 8:454-459
* D. Koshland and,A. Strunnikov(1996) Mitotic chromosome condensation.Annual Reviews of Cell and Developmental Biology12:305-333