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專家人才

  • 姓名：徐進新
  • 性別：男
  • 職稱：副研究員
  • 學曆：博士
  • 電話：020-32015240
  • 傳真：
  • 電子郵件:xu_jinxin@gibh.ac.cn
  • 通訊地址廣州科學城開源大道190號

    簡曆：

  • 　　2017.1　至今betway体育下载 副研究員

    2012.7—2016.12betway体育下载 助理研究員

    2006.9—2012.6中國科學技術大學結構生物學專業博士

    2002.9—2006.6江西師範大學生物科學專業學士

    研究領域：

  • 　　生物大分子結構與功能

    承擔科研項目情況：

    社會任職：

    獲獎及榮譽：

    代表論著：

  • 1.Xu, J#., Zhang, L#., Ye, Y., Shan, Y., Wan, C., Wang, J., Shu, X., & Liu, J. (2017). SNX16 Regulates the Recycling of E-Cadherin through a Unique Mechanism of Coordinated Membrane and Cargo Binding. Structure, 2017, 25(8), 1251-1263 (#co-First authors)

    2.Su, K., Xu, T., Yu, Z., Zhu, J., Zhang, Y., Wu, M., Xiong Y., Liu, J., &Xu, J*. (2017). Structure of the PX domain of SNX25 reveals a novel phospholipid recognition model by dimerization in the PX domain. FEBS letters, 591(13), 2011-20182. (* Corresponding author)

    3.Wu, Y., Xu, T., Liu, J., Ding, K*., &Xu, J*. Structural insights into the binding mechanism of IDO1 with hydroxylamidine based inhibitor INCB14943. Biochem Biophys Res Commun, 2017, 487(2):339-343. (* co-Corresponding author)

    4.Hou, S., Xu, T.,Xu, J., Qu, L., Xu, Y., Chen, L., & Liu, J. (2017). Structural basis for functional selectivity and ligand recognition revealed by crystal structures of human secreted phospholipase A2 group IIE. Scientific Reports, 2017, 7

    5.Lan, D., Xu, H.,Xu, J., Dubin, G., Liu, J., Iqbal Khan F., &Wang, Y. Malassezia globosa MgMDL2 lipase: Crystal structure and rational modification of substrate specificity. Biochem Biophys Res Commun, 2017, pii: S0006-291X(17)30778-7.

    6.Zhu, Y#.,Xu, J#., Mei, X#., Feng, Z., Zhang, L., Zhang, Q., ... & Zhang, C. Biochemical and Structural Insights into the Aminotransferase CrmG in Caerulomycin Biosynthesis. ACS Chemical Biology, 2016, 11, 943–952. (#co-First authors)

    7.Guo, S#.,Xu, J#., Pavlidis, I. V., Lan, D., Bornscheuer, U. T., Liu, J., & Wang, Y. Structure of product‐bound SMG1 lipase: active site gating implications. FEBS Journal, 2015, 282(23), 4538-4547. (#co-First authors)

    8.Lan, D., Wang, Q.,Xu, J., Zhou, P., Yang, B., & Wang, Y. Residue Asn277 affects the stability and substrate specificity of the SMG1 lipase from Malassezia globosa. International Journal of Molecular Sciences, 2015, 16(4), 7273-7288.

    9.Xu, T.,Xu, J., Ye, Y., Wang, Q., Shu, X., Pei, D., & Liu, J. Structure of human SNX10 reveals insights into its role in human autosomal recessive osteopetrosis. Proteins: Structure, Function, and Bioinformatics, 2014, 82(12), 3483-3489.

    10.Xu, J#., Xu, T., Wu, B., Ye, Y., You, X., Shu, X., ... & Liu, J. Structure of sorting nexin 11 (SNX11) reveals a novel extended phox homology (PX) domain critical for inhibition of SNX10-induced vacuolation. Journal of Biological Chemistry, 2013, 288(23), 16598-16605. (#First author)

    11.Xu, T., Liu, L., Hou, S.,Xu, J., Yang, B., Wang, Y., & Liu, J. Crystal structure of a mono-and diacylglycerol lipase from Malassezia globosa reveals a novel lid conformation and insights into the substrate specificity. Journal of Structural Biology, 2012, 178(3), 363-369.

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