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專家人才

  • 姓名：熊曉犁
  • 性別：男
  • 職稱：研究員
  • 學曆：博士
  • 電話：
  • 傳真：
  • 電子郵件:xiong_xiaoli@gibh.ac.cn
  • 通訊地址廣州市黃埔區開源大道190號

    簡曆：

  • 熊曉犁，博士，研究員，廣東省珠江人才計劃青年拔尖人才，英國微生物學會會員。在英國布裏斯托大學生物化學係/細胞和分子醫學係分別獲得生物化學與生物技術學士學位和病理學與微生物學博士學位。熊曉犁研究員先後在英國MRC National Institute for Medical Research (現Francis Crick Institute)病毒學係Sir John Skehel研究組，美國華盛頓大學（西雅圖）生物化學係，英國MRC Laboratory of Molecular Biology結構生物學係從事病原微生物致病機理的研究。2020年9月加入betway体育下载 。

    近10年來熊曉犁研究員研究了H5N1, H7N9, H10N8流感病毒的跨種傳播機理（Xionget.al.Nature2013a,Xionget.al.Nature2013b,Xionget.al.Virology2014, Vachieri*,Xiong.* et. al.Nature2014）,流感病毒的裝配機製 （Peukes*,Xiong*#et.al.Nature2020）。冠狀病毒的入侵機製(Xionget.al.J. Virology2018, Walls*,Xiong* et.al.Cell2019),新型冠狀病毒表麵抗原S蛋白的穩定化（Xiong*#et.al.Nat. Struct. Mol. Biol.2020）等科學問題。研究團隊旨在運用結構生物學與生物化學方法探明病原微生物的致病機理，並在理解其致病機理的基礎上開發幹預手段。

    研究領域：

    承擔科研項目情況：

    社會任職：

    獲獎及榮譽：

    代表論著：

  • 1.Xiong, X.*#, Qu, K.*, Ciazynska, K.A., Hosmillo, M., Carter, A.P., Ebrahimi, S., Ke, Z., Scheres, S.H.W., Bergamaschi, L., Grice, G.L., Zhang, Y., The CITIID-NIHR COVID-19 Bioresource, Nathan, J.A., Baker, S., James, L.C., Helen, E., Goodfellow, I., Doffinger, R., and Briggs, J.A.G. # (2020). A thermostable, closed, SARS-CoV-2 spike protein trimer.Nat. Struct. Mol. Biol.

    2.Peukes, J.*,Xiong, X.*#, Erlendsson, S., Qu, K., Wan, W., Leslie, J., Schraidt, O., Kummer, S., Freund, S.M.V., Kraeusslich H-G., Briggs, J.A.G #. (2020). The native structure of the assembled matrix protein 1 of influenza A virus.Nature.

    3.Zunlong Ke, Oton, J., Qu, K., Cortese, M., Zila, V., McKeane, L., Nakane, T., Zivanov, J., Neufeldt2, C.J., Lu, J.M., Peukes, J.,Xiong, X., Kraeusslich, H-G., Scheres, S.H.W., Bartenschlager, R., Briggs, J.A.G. (2020). Structures, conformations and distributions of SARS-CoV-2 spike protein trimers on intact virions.Nature.

    4.Mlcochova, P., Collier, D., Ritchie, A. V, Assennato, S.M., Hosmillo, M., Goel, N., Meng, B., Chatterji, K., Mendoza, V., Temperton, N., Kiss, L., Ciazyns, K.A.,Xiong, X., Briggs, J.A.G., Nathan, J., Mescia, F., Zhang, H., Barmpounakis, P., Demeris, N., et al. (2020). Combined point of care SARS-CoV-2 nucleic acid and antibody testing in suspected moderate to severe COVID-19 disease.Cell Reports Medicine.

    5.Zheng, A., Sun, W.,Xiong, X., Freyn, A.W., Peukes, J., Stromeier, S., Nachbagauer, R., Briggs, J.A.G., Krammer, F., and Palese, P. (2020). Enhancing Neuraminidase Immunogenicity of Influenza A Viruses by Rewiring RNA Packaging Signals.J. Virol..

    6.Gamblin, S.J., Vachieri, S.G.,Xiong, X., Zhang, J., Martin, S.R., and Skehel, J.J. (2020). Hemagglutinin Structure and Activities.Cold Spring Harb. Perspect. Med.a038638.

    7.Walls, A. C.*,Xiong, X.*, Park, Y, Tortorici, M.A., Snijder, J., Quispe, J., Cameroni, E., Dai, M., Zambon, M., Rey, F. A., Corti, D., Veesler, D. (2019). Unexpected receptor functional mimicry elucidates activation of coronavirus fusion.Cell176,1026-1039

    8.Xiong, X.,Tortorici, M. A., Snijder, J., Yoshioka, C., Walls, A. C., Li, W., McGuire, A. T., Rey, F. A., Bosch, B., Veesler, D., (2018) Glycan shield and fusion activation of a deltacoronavirus spike glycoprotein fine-tuned for enteric infections.J. Virology,92, e01628-17

    9.Walls, A. C, Tortorici, M. A, Snijder, J,Xiong, X, Bosch, B. J, Rey, F. A and Veesler, D., (2017) Tectonic conformational changes of a coronavirus spike glycoprotein promote membrane fusion.Proc Natl Acad Sci. U S A114:11157-11162.

    10.Xiong, X., Corti, D., Liu, J., Pinna, D., Foglierini, M., Calder, L.J., Martin, S. R., Lin, Y.P., Walker, P. A., Collins, P. J., Moine, I., Suguitan Jr., A.L., Santos, C., Temperton, N.J., Subbarao, K., Lanzavecchia, A., Gamblin, S.J., Skehel, J. J., (2015) Structures of complexes formed by H5 influenza haemagglutinin with a potent broadly neutralizing human monoclonal antibody.Proc Natl Acad Sci U S A112, 9430-9435.

    11.Xiong, X. McCauley, J.W., Steinhauer, D.A. (2014). Receptor Binding Properties of the Influenza Virus Hemagglutinin as a Determinant of Host Range.Curr Top Microbiol Immunol385, 63-91

    12.Vachieri, S.G.*,Xiong, X.*, Collins, P.J., Walker, P.A., Martin, S.R., Haire, L.F., Zhang, Y., McCauley, J.W., Gamblin, S.J., and Skehel, J.J. (2014). Receptor binding by H10 influenza viruses.Nature511, 475-477.

    13.Xiong, X.*, Xiao, H.*, Martin, S. R., Coombs, P. J., Liu, J., Collins, P. J., Vachieri, S. G., Walker, P. A., Lin, Y. P., McCauley, J. W., Gamblin, S. J. & Skehel, J. J. (2014). Enhanced human receptor binding by H5 haemagglutinins.Virology,456-457, 179-187.

    14.Xiong, X., Tuzikov, A., Coombs, P. J., Martin, S., Walker, P. A., Gamblin, S. J., Bovin, N. & Skehel, J. J. (2013). Recognition of sulphated and fucosylated receptor sialosides by A/Vietnam/1194/2004 (H5N1) influenza virus.Virus Res,178, 12-4.

    15.Xiong, X., Martin, S. R., Haire, L. F., Wharton, S. A., Daniels, R. S., Bennett, M. S., McCauley, J. W., Collins, P. J., Walker, P. A., Skehel, J. J. & Gamblin, S. J. (2013). Receptor binding by an H7N9 influenza virus from humans.Nature,499, 496-9.

    16.Xiong, X.*, Coombs, P. J.*, Martin, S. R.*, Liu, J., Xiao, H., McCauley, J. W., Locher, K., Walker, P. A., Collins, P. J., Kawaoka, Y., Skehel, J. J. & Gamblin, S. J. (2013). Receptor binding by a ferret-transmissible H5 avian influenza virus.Nature,497, 392-6.

    17.Lin, Y. P.*,Xiong, X.*, Wharton, S. A., Martin, S. R., Coombs, P. J., Vachieri, S. G., Christodoulou, E., Walker, P. A., Liu, J., Skehel, J. J., Gamblin, S. J., Hay, A. J., Daniels, R. S. & McCauley, J. W. (2012). Evolution of the receptor binding properties of the influenza A(H3N2) hemagglutinin.Proc Natl Acad Sci U S A,109, 21474-9.

    18.Xiong, X., Bromley, E. H., Oelschlaeger, P., Woolfson, D. N. & Spencer, J. (2011). Structural insights into quinolone antibiotic resistance mediated by pentapeptide repeat proteins: conserved surface loops direct the activity of a Qnr protein from a gram-negative bacterium.Nucleic Acids Res,39, 3917-27.

    l共同第一作者。#共同通訊作者。

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