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專家人才

  • 姓名:楊樂樂
  • 性別:
  • 職稱:副研究員
  • 學曆:碩士
  • 電話:
  • 傳真:
  • 電子郵件:yang_lele@gibh.ac.cn
  • 通訊地址廣州市黃埔區開源大道190號

    簡曆:

  • 1998-092002-06,吉林農業大學,動物藥學,學士

    2002-092005-06,華中農業大學,預防獸醫學,碩士

    2005-072007-06,中國科學院動物研究所,生物膜與膜生物工程國家重點實驗室模式動物與幹細胞研究小組,研究實習員

    2007-092009-12,betway体育下载 ,細胞譜係與發育研究中心,研究實習員

    2010-012021-12,betway体育下载 ,細胞譜係與發育研究中心,助理研究員

    2021-12,betway体育下载 ,細胞譜係與發育研究中心,副研究員

    研究領域:

  • 主要從事小鼠雄性生殖幹細胞自我更新與分化的分子調控機製研究。

    承擔科研項目情況:

    社會任職:

    獲獎及榮譽:

    代表論著:

  • 1.Lele Yang, Wei Wu, Huayu Qi.Gene expression profiling revealed specific spermatogonial stem cell genes in mouse. Genesis, 2013Feb;51(2):83–96.

    2.Lele Yang#, Dongsheng Chen#, Ranhui Duan#, Laixin Xia, Jun Wang, Abrar Qurashi, Peng Jin*, Dahua Chen*.Argonaute 1 protein regulates the fate of germline stem cell in Drosophila. Development, 2007 Dec; 134(23):4265-4272.

    3.Lele Yang#, Ranhui Duan#, Dongsheng Chen, Jun Wang, Dahua Chen*, Peng Jin*. Fragile X mental retardation protein modulates the fate of germline stem cells in Drosophila. Human Molecular Genetics , 2007 Aug ;16(15):1814-1820.

    4.Qianxing Zou,Lele Yang, Ruona Shi, Yuling Qi, Xiaofei Zhang, Huayu Qi. Proteostasis regulated by testis-specific ribosomal protein RPL39L maintains mouse spermatogenesis. iScience. 2021 Dec;24(12):103396.

    5.Kunyu Shi,Lele Yang, Xueqing Zhuang, Lan Zhang*, and Huayu Qi*.Yeast Two-Hybrid Screen Identifies PKA-Riα Interacting Proteins during Mouse Spermiogenesis. Genes. 2021, Nov 30;12(12), 1941.

    6.Jinyue Liao, Hoi Ching Suen, Alfred Chun Shui Luk,Lele Yang, Annie Wing Tung Lee, Huayu Qi, Tin-Lap Lee. Transcriptomic and epigenomic profiling of young and aged spermatogonial stem cells reveals molecular targets regulating differentiation. PLoS Genetics. 2021 Jul 8;17(7):e1009369.

    7.Qing Xia, Guizhong Cui, Ye Fan, Xiuqin Wang, Gongcheng Hu, Lisha Wang, Xi Luo,Lele Yang, Qingqing Cai, Kaibiao Xu, Wenjing Guo, Minghui Gao, Yingying Li, Ji Wu, Wei Li, Jiayu Chen, Huayu Qi, Guangdun Peng, Hongjie Yao. RNA helicase DDX5 acts as a critical regulator for survival of neonatal mouse gonocytes. Cell Proliferation. 2021 May;54(5):e13000.

    8.Kaibiao Xu,Lele Yang, Lan Zhang and Huayu Qi. Lack of AKAP3 disrupts integrity of the subcellular structure and proteome of mouse sperm and causes male sterility. Development. 2020 Jan;147(2):1-15.

    9.Zhuxia Zheng, Hongmei Li, Qinfen Zhang,Lele Yangand Huayu Qi.Unequal distribution of 16S mtrRNA at the 2-cell stage regulates cell lineage allocations in mouse embryos.Reproduction,2016Apr;151(4):351–367.

    10.Xiaoyong Jiang, Laixin Xia, Dongsheng Chen, Yingyue Yang, Haidong Huang,Lele Yang, Qiudong Zhao,Lijun Shen, Jun Wang,Dahua Chen. Otefin, a nuclear membrane protein, determines the fate of germline stem cells in Drosophila via interaction with Smad complexes. Developmental cell, 2008 Apr; 14(4):494-506.

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