2007年09月-2011年07月安徽大學生命科學學院生物工程工學學士

2011年09月-2016年07月betway体育下载 發育生物學理學博士

2016年07月-2017年12月betway体育下载 助理研究員

2018年01月-2018年06月betway体育下载 副研究員（試聘）

2018年07月-2022年12月betway体育下载 副研究員

2022年12月-至今betway体育下载 研究員

基因修飾大動物模型構建與應用；

新型基因編輯技術開發與優化。

1.國家自然科學基金麵上項目（2022.01-2025.12），項目負責人；

2.國家重點研發計劃項目（2021.12-2026.11），子課題負責人；

3.國家自然科學基金專項項目（2020.01-2022.12），項目負責人；

4.國家自然科學基金青年科學基金項目（2018.01-2020.12），項目負責人；

5.海南省重點研發計劃項目（2021.09-2023.09），項目負責人；

6.中國科學院戰略生物資源能力建設項目（2020.01-2021.12），項目負責人。

廣東省遺傳學會理事、副秘書長；

中國科學院青年創新促進會廣州分會第三屆、第四屆委員會委員。

中國科協青年人才托舉工程項目入選者；

中國科學院青年創新促進會會員。

1.Qin Jin^#, Xiaoyi Liu^#, Zhenpeng Zhuang^#, Jiayuan Huang^#, Shixue Gou, Hui Shi, Yu Zhao, Zhen Ouyang, Zhaoming Liu, Lei Li, Junjie Mao, Weikai Ge, Fangbing Chen, Manya Yu, Yezhi Guan, Yinghua Ye, Chengcheng Tang, Ren Huang,Kepin Wang*, Liangxue Lai*, Doxycycline-dependent Cas9-expressing pig resources for conditionalin vivogene nullification and activation,Genome Biology, 2023, 24:8.

2.Xunlei Wang^#, Qin Jin^#, Wenwen Xiao^#, Puxian Fang, Liangxue Lai, Shaobo Xiao,Kepin Wang*, Liurong Fang*, Genome-wide CRISPR/Cas9 screen reveals a role for SLC35A1 in the adsorption of porcine deltacoronavirus,Journal of Virology,2022, 96(24):e0162622.

3.Qin Jin^#, Xiaoyu Yang,Shixue Gou, Xiaoyi Liu, Zhenpeng Zhuang, Yanhui Liang, Hui Shi, Jiayuan Huang, Han Wu, Yu Zhao, Zhen Ouyang, Quanjun Zhang, Zhaoming Liu, Fangbing Chen, Weikai Ge, Jingke Xie, Nan Li, Chengdan Lai, Xiaozhu Zhao, Jiaowei Wang, Meng Lian, Lei Li,Longquan Quan, Yinghua Ye,Liangxue Lai*,Kepin Wang*,Double knock-in pig models with elements of binary Tet-On and phiC31 integrase systems for controllable and switchable gene expression,Science China Life Sciences, 2022, 65(11):2269-2286.

4.Yanhui Liang^#, Jingke Xie^#, Quanjun Zhang^#,Xiaomin Wang^#, Shixue Gou, Lihui Lin, Tao Chen, Weikai Ge, Zhenpeng Zhuang, Meng Lian, Fangbing Chen, Nan Li, Zhen Ouyang, Chengdan Lai, Xiaoyi Liu, Lei Li, Yinghua Ye, Han Wu,Kepin Wang*, Liangxue Lai*,AGBE: A dual deaminase-mediated base editor by fusing CGBE with ABE for creating a saturated mutant population with multiple editing patterns,Nucleic Acids Research, 2022,50(9):5384-5399.

5.Nan Li^#, Shixue Gou^#, Jiaowei Wang^#, Quanjun Zhang, Xingyun Huang, Jingke Xie, Li Li, Qin Jin, Zhen Ouyang, Fangbing Chen, Weikai Ge, Hui Shi, Yanhui Liang, Zhenpeng Zhuang, Xiaozhu Zhao, Meng Lian, Yinghua Ye, Longquan Quan, Han Wu*, Liangxue Lai*,Kepin Wang*,CRISPR/Cas9-mediated gene correction in newborn rabbits with hereditary tyrosinemia type I,Molecular Therapy, 2021, 29(3):1001-1015.

6.Meng Lian^#, Fangbing Chen^#, Xingyun Huang^#, Xiaozhu Zhao, Shixue Gou, Nan Li, Qin Jin, Hui Shi, Yanhui Liang, Jingke Xie, Weikai Ge, Zhenpeng Zhuang, Jiaowei Wang, Yinghua Ye, Yi Yang,Kepin Wang*, Liangxue Lai*, Han Wu*,Improving Cpf1-mediated base editing system by combining dCas9/ dead sgRNA with human APOBEC3A variants,Journal of Genetics and Genomics, 2021, 48(1):92-95.

7.Wenjing Li^#, Lei Shi^#, Zhenpeng Zhuang^#, Han Wu^#, Meng Lian, Yihui Chen, Lei Li, Weikai Ge, Qin Jin, Quanjun Zhang, Yu Zhao, Zhaoming Liu, Zhen Ouyang, Yinghua Ye, Yingying Li, Hai Wang, Yuan Liao, Longquan Quan, Lei Xiao, Liangxue Lai*, Guangxun Meng*,Kepin Wang*,Engineered pigs carrying a gain-of-function NLRP3 homozygous mutation can survive to adult and accurately recapitulate human systemic spontaneous inflammatory responses,Journal of Immunology, 2020, 205(9):2532-2544.

8.Jingke Xie^#, Xingyun Huang^#, Xia Wang, Shixue Gou, Yanhui Liang, Fangbing Chen, Nan Li, Zhen Ouyang, Quanjun Zhang, Weikai Ge, Qin Jin, Hui Shi, Zhenpeng Zhuang, Xiaozhu Zhao, Meng Lian, Jiaowei Wang, Yinghua Ye, Longquan Quan, Han Wu,Kepin Wang*, Liangxue Lai*,ACBE, a new base editor for simultaneous C-to-T and A-to-G substitutions in mammalian systems,BMC Biology, 2020,18:131.

9.Jingke Xie^#, Weikai Ge^#, Nan Li^#, Qishuai Liu^#, Fangbing Chen, Xiaoyu Yang, Xingyun Huang, Zhen Ouyang, Quanjun Zhang, Yu Zhao, Zhaoming Liu, Shixue Gou, Han Wu, Chengdan Lai, Nana Fan, Qin Jin, Hui Shi, Yanhui Liang, Ting Lan, Longquan Quan, Xiaoping Li,Kepin Wang*, Liangxue Lai*,Efficient base editing for multiple genes/loci in pigs using base editors,Nature Communications, 2019, 10:2852.

10.Han Wu^#, Qishuai Liu^#, Hui Shi, Jingke Xie, Quanjun Zhang, Zhen Ouyang, Nan Li, Yi Yang, Zhaoming Liu, Yu Zhao, Chengdan Lai, Degong Ruan, Jiangyun Peng, Weikai Ge, Fangbing Chen, Nana Fan, Qin Jin, Yanhui Liang, Ting Lan, Xiaoyu Yang, Xiaoshan Wang, Zhiyong Lei, Pieter A. Doevendans, Joost P. G. Sluijter,Kepin Wang*, Xiaoping Li*, Liangxue Lai*,Engineering CRISPR/Cpf1 with tRNA promotes genome editing capability in mammalian systems,Cellular and Molecular Life Sciences, 2018, 75(19):3593-3607.

11.Degong Ruan^#, Jiangyun Peng^#, Xiaoshan Wang^#, Zhen Ouyang^#, Yi Yang, Fangbing Chen, Weikai Ge, Han Wu, Zhaoming Liu, Yu Zhao, Bentian Zhao, Quanjun Zhang, Chengdan Lai, Nana Fan, Zhiwei Zhou, Qishuai Liu, Nan Li, Qin Jin, Hui Shi, Jingke Xie, Xiaoyu Yang, Hong Song,Kepin Wang*, Xiaoping Li*, Liangxue Lai*,Xist derepression in active X chromosome hinders pig somatic cell nuclear transfer,Stem Cell Reports, 2018, 10(2): 494-508.

12.Kepin Wang^#, Qin Jin^#, Degong Ruan^#, Yi Yang, Qishuai Liu, Han Wu, Zhiwei Zhou, Zhen Ouyang, Zhaoming Liu, Yu Zhao, Bentian Zhao, Quanjun Zhang, Jiangyun Peng, Chengdan Lai, Nana Fan, Yanhui Liang, Ting Lan, Nan Li, Xiaoshan Wang, Xinlu Wang, Yong Fan, Pieter A. Doevendans, Joost P.G. Sluijter, Pentao Liu, Xiaoping Li*, Liangxue Lai*,Cre-dependent Cas9-expressing pigs enable efficient in vivo genome editing,Genome Research, 2017, 27(12): 2061-2071.

13.Yi Yang^#,Kepin Wang^#, Han Wu, Qin Jin, Degong Ruan, Zhen Ouyang, Bentian Zhao, Zhaoming Liu, Yu Zhao, Quanjun Zhang, Nana Fan, Qishuai Liu, Shimei Guo, Lei Bu, Yong Fan, Xiaofang Sun,Xiaoping Li*, Liangxue Lai*,Genetically humanized pigs exclusively expressing human insulin are generated through custom endonuclease-mediated seamless engineering,Journal of Molecular Cell Biology, 2016, 8(2): 174-177.