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專家人才

  • 姓名：唐士兵
  • 性別：男
  • 職稱：研究員
  • 學曆：博士
  • 電話：
  • 傳真：
  • 電子郵件:tang_shibing@gibh.ac.cn
  • 通訊地址廣州市黃埔區開源大道190號

    簡曆：

  • 時間

    單位/職位

    2002—2006

    吉林大學/學士

    2006—2011

    蘭州大學/博士

    2011—2017

    加州大學舊金山分校/博士後

    2017—至今

    betway体育下载 /課題組長，研究員

    研究領域：

  • 唐士兵博士主要運用藥物化學和化學生物學等學科的技術手段發現活性分子並將其應用於化學生物學基礎研究和創新藥物發現，特別是針對惡性腫瘤和代謝性疾病等疾病的新型靶標進行新分子實體發現和臨床前研究。

    研究方向包括：1）惡性腫瘤、代謝性疾病等疾病的藥物研發；2）生物活性工具分子的設計合成和應用研究；3）小分子藥物的合成策略和工藝優化；

    承擔科研項目情況：

    社會任職：

    獲獎及榮譽：

    代表論著：

  • 01.Liu X,Zhang Y,Chu Y,Zhao X,Mao L,Zhao S,Lin S,Hui X,Gu P,Xu Y,LoomesK,Tang S*, Nie T*, Wu D*. The natural compound rutaecarpine promotes white adipocyte browning through activation of the AMPK-PRDM16 axis. Biochem Biophys Res Commun. 2021;545:189-194.PMID: 33561654

    02.Tan J, Liu H, Huang M, Li N,Tang S, Meng J, Tang S, Zhou H, Kijlstra A, Yang P, Hou S.Small molecules targeting RORγt inhibit autoimmune disease by suppressing Th17 cell differentiation.Cell Death Dis. 2020 Aug 22;11(8):697. PMID:32829384

    03. Zhao S, Chu Y, Zhang Y, Zhou Y, Jiang Z, Wang Z, Mao L, Li K, Sun W, Li P, Jia S, Wang C, Xu A, Loomes K,Tang S, Wu D, Hui X, Nie T.Linifanib exerts dual anti-obesity effect by regulating adipocyte browning andformation. Life Sci. 2019 Apr 1;222:117-124. PMID: 30708100

    04. Sun W, Zhao X, Wang Z, Chu Y, Mao L, Lin S, Gao X, Song Y, Hui X, Jia S,Tang S, Xu Y, Xu A, Loomes K, Wang C, Wu D, Nie T. Tbx15 is required for adipocyte browning induced by adrenergic signaling pathway. Mol Metab. 2019 Oct;28:48-57. PMID: 31352005

    05. Hou L#, Yang G#,Tang S#,Alcazar C, Joshi P, Strassberg Z, Kim M, Kawamura M, Woo YJ, Shrager J,Ding S,Huang NF.A small molecule derived fromcarboxyethylpyrroleprotein adducts promotes angiogenesis in a mouse model of peripheral arterialdisease.J Am Heart Assoc. 2018Sep 18;7(18):e009234.PMID: 30371212

    06. Qin Y#,Tang S#, Zhen G, Ding Q, Ding S, Cao X. Bone-targeted delivery of TGF-β type 1 receptor inhibitor rescues uncoupled bone remodeling in Camurati-Engelmann disease. Ann N Y Acad Sci. 2018 Dec; 1433(1):29-40. PMID:30091466

    07. Yang B#,Tang S#, Ma C#, Li ST, Kobayashi T, Hoppmann C, Dang B, DeGrado WF, Dong MQ, Wang PG, Ding S, Wang L. Spontaneous and specific chemical cross-linking in live cells to capture and identify protein interactions. Nat Commun. 2017 Dec 21;8(1):2240. PMID: 29269770

    08. Xie M#,Tang S#, Li K, Ding S.Pharmacological reprogramming of somatic cells for regenerative medicine.Acc Chem Res. 2017 May 16; 50(5):1202-1211.PMID: 28453285.

    09. Mohamed TMA, Stone NR, Berry EC, Radzinsky E, Huang Y, Pratt K, Ang Y, Yu P, Wang H,Tang S, Magnitsky S, Ding S, Ivey KN, Srivastava D.Chemical enhancement of in vitro and in vivo direct cardiac reprogramming. Circulation. 2017 Mar 7; 135(10):978-995.PMID: 27834668. (Reported by a number of major media reports, including ABC 7, Fierce Biotech, Daily Mail, etc.)

    10. Nie B, Nie T, Hui X, Gu P, Mao L, Li K, Yuan R, Zheng J, Wang H, Li K,Tang S, Zhang Y, Xu T, Xu A, Wu D, Ding S.Brown adipogenic reprogramming induced by a small molecule.Cell Rep.2017 Jan 17;18(3):624-635. PMID: 28099842.

    11. Nakamura PA, Shimchuk AA,Tang S, Wang Z, Degolier K, Ding S, Reh TA. Small molecule Photoregulin3 prevents retinal degeneration in the RhoP23Hmouse model of Retinitis Pigmentosa. eLife 2017 Nov 17; 6. pii: e30577. PMID: 29148976.

    12. Nakamura PA,Tang S, Shimchuk AA, Ding S, Reh TA.Potential of small molecule-mediated reprogramming of rod photoreceptors to treat retinitis pigmentosa.Invest Ophthalmol Vis Sci.2016Nov 1; 57(14):6407-6415. PMID: 27893103. (Reported by Foundation Fighting Blindness)

    13.Tang S#, Xie M#, Cao N, Ding S.Patient-specific induced pluripotent stem cells for disease modeling and phenotypic drug discovery.J Med Chem. 2016Jan 14; 59(1):2-15. PMID: 26322868.

    14. Zhu S, Russ HA, Wang X, Zhang M, Ma T, Xu T,Tang S, Hebrok M, Ding S. Human pancreatic beta-like cells converted from fibroblasts. Nat Commun. 2016 Jan 6; 7:10080. PMID: 26733021. (Reported by a number of major media reports, including Fox News, The Independent, SF Business Times,etc.)

    15. Yu C#, Liu K#,Tang S#, Ding S. Chemical approaches to cell reprogramming.Curr Opin Genet Dev.201
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