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專家人才

  • 姓名：李文娟
  • 性別：女
  • 職稱：副研究員
  • 學曆：
  • 電話：
  • 傳真：
  • 電子郵件:li_wenjuan@gibh.ac.cn
  • 通訊地址廣州市黃埔區開源大道190號

    簡曆：

  • 2008.09—2012.06河南師範大學生命科學學院，生物科學專業學士；

    2012.09—2017.12betway体育下载 ，細胞生物學

    2018.01—2020.02廣醫-廣州生物院聯合生科院,博士後

    2020.03—2022.12betway体育下载 ,特別研究助理

    2023.01至今betway体育下载 ,副研究員

    研究領域：

  • 早期胚胎發育中的譜係調控機製

    多能性和全能性轉換機理

    利用全能性細胞構建功能性組織細胞或類器官

    承擔科研項目情況：

  • 1. 作為負責人主持項目

    1) TGFβ信號通路介導的上皮-間質轉換在合子基因組激活中的調控研究（國家自然科學基金青年科學基金項目，32200669，30萬）

    2) WNT/β-catenin信號通路通過TBX3調節人類原始態多能性（中國博士後科學基金麵上資助一等資助，2019M650195，12萬）

    3) STELLA介導的DNA被動去甲基化在人類原始態誘導中的功能研究（廣州市科技計劃項目基礎研究計劃，2021000122，5萬）

    2. 作為參與人參加項目：

    1) RNA表觀轉錄修飾及其相關的RNA結合蛋白和蛋白翻譯後修飾對人幹細胞多能性的調控及分子機製研究（國家重點研發計劃2018YFA0106903，項目骨幹）

    2) 基態多能幹細胞的轉錄延伸調控（國家自然科學基金麵上項目31671537）

    3) NANOG在人原始態多能幹細胞誘導和維持中的作用機製研究（國家自然科學基金青年基金項目31601184）

    4) 利用幹細胞理解和治愈帕金森病（廣州再生醫學與健康廣東省實驗室創新團隊項目2018GZR110103001）。

    社會任職：

    獲獎及榮譽：

    代表論著：

  • 1. Mazid Md. Abdul*#, Carl Ward#, Zhiwei Luo#, Chuanyu Liu#, Yunpan Li, Yiwei Lai, Liang Wu, Jinxiu Li, Wenqi Jia, Yu Jiang, Hao Liu, Lixin Fu, Yueli Yang, David P. Iba？ez, Junjian Lai, Xiaoyu Wei, Juan An, Pengcheng Guo, Yue Yuan, Qiuting Deng, Yang Wang, Ying Liu, Fei Gao, Junwen Wang, Shahriar Zaman, Baoming Qin, Guangming Wu, Patrick H. Maxwell, Xun Xu, Longqi Liu*,Wenjuan Li*,Miguel A. Esteban* (2022). Rolling back of human pluripotent stem cells to an 8-cell embryo-like stage.Nature605: 315-324.（影響因子69.5）*Corresponding author,#First author.

    2. Qiang Zhuang#,Wenjuan Li#, Christina Benda#, Zhijian Huang, Tanveer Ahmed, Ping Liu, Xiangpeng Guo, David P. Iba？ez, Zhiwei Luo, Meng Zhang, Mazid MD. Abdul, Zhongzhou Yang, Jiayin Yang, Yinghua Huang, Hui Zhang, Dehao Huang, Jianguo Zhou, Xiaofen Zhong, Xihua Zhu, Xiuling Fu, Wenxia Fan, Yulin Liu, Yan Xu, Carl Ward, Muhammad J. Khan, Shahzina Kanwal, Bushra Mirza, Micky D. Tortorella, Hung-Fat Tse, Jiayu Chen, Baoming Qin, Xichen Bao, Shaorong Gao, Andrew P. Hutchins* and Miguel A. Esteban*(2018). "NCoR/SMRT co-repressors cooperate with c-MYC to create an epigenetic barrier to somatic cell reprogramming."Nature Cell Biology20(4): 400-412.(影響因子28.2)*Corresponding author,#First author.

    3. Yunpan Li#, David P. Ibanez, Wenxia Fan, Ping Zhao, Shuhan Chen, Mazid Md. Abdul, Yu Jiang, Lixin Fu, Zhiwei Luo, Zhenhua Liu, Yueli Yang, Jifeng Guo, Giacomo Volpe, Shahzina Kanwal, Dongye Wang, Beisha Tang* andWenjuan Li*(2020). "Generation of an induced pluripotent stem cell line (GIBHi004-A) from a Parkinson's disease patient with mutant DJ-1/PARK7 (p.L10P)."Stem Cell Research46: 101845.(影響因子1.6)*Corresponding author,#First author.

    4. Zhiwei Luo#, Xiaobing Qing, Christina Benda, Zhijian Huang, Meng Zhang, Yinghua Huang, Hui Zhang, Lulu Wang, Yiwei Lai, Carl Ward, Giacomo Volpe, Xiaofen Zhong, Baoming Qin, Qiang Zhuang*, Miguel A. Esteban andWenjuan Li* (2019). "Nuclear-cytoplasmic shuttling of class IIa histone deacetylases regulates somatic cell reprogramming."Cell Regeneration8(1):21-29. *Corresponding author,#First author.

    5. Li Chen, Qiaoqiao Tong, Xiaowen Chen, Penglei Jiang, Hua Yu, Qianbing Zhao, Lingang Sun, Chao Liu, Bin Gu, Yuping Zheng, Lijiang Fei, Xiao Jiang,Wenjuan Li,Giacomo Volpe, Mazid MD. Abdul, Guoji Guo, Jin Zhang, Pengxu Qian, Qiming Sun, Dante Neculai, Miguel A. Esteban, Chen Li, Feiqiu Wen and Junfeng Ji (2021). "PHC1 maintains pluripotency by organizing genome-wide chromatin interactions of the Nanog locus."Nature Communications12(1): 2829.

    6. Isaac A. Babarinde, Gang Ma, Yuhao Li, Boping Deng, Zhiwei Luo, Hao Liu, Mazid Md. Abdul, Carl Ward, Minchun Chen, Xiuling Fu, Liyang Shi, Martha Duttlinger, Jiangping He, Li Sun,Wenjuan Li, Qiang Zhuang, Guoqing Tong, Jon Frampton, Jean-Baptiste Cazier, Jiekai Chen, Ralf Jauch, Miguel A. Esteban and Andrew P. Hutchins (2021). "Transposable element sequence fragments incorporated into coding and noncoding transcripts modulate the transcriptome of human pluripotent stem cells."Nucleic Acids Research49(16):9132-9153.

    7. Meng Zhang, Yiwei Lai, Vladislav Krupalnik, Pengcheng Guo, Xiangpeng Guo, Jianguo Zhou, Yan Xu, Zhijun Yu, Longqi Liu, Ao Jiang,Wenjuan Li,Mazid Md. Abdul, Gang Ma, Na Li, Xiuling Fu, Yuan Lv, Mengling Jiang, Muqddas Tariq, Shahzina Kanwal, Hao Liu, Xueting Xu, Hui Zhang, Yinghua Huang, Lulu Wang, Shuhan Chen, Isaac A. Babarinde, Zhiwei Luo, Dongye Wang, Tiantian Zhou, Carl Ward, Minghui He, David P. Iban？ez, Yunpan Li, Jiajian Zhou, Jie Yuan, Yayan Feng, Karthik Arumugam, Umberto Di Vicino, Xichen Bao, Guangming Wu, Axel Schambach, Huating Wang, Hao Sun, Fei Gao, Baoming Qin, Andrew P. Hutchins, Bradley W. Doble, Christine Hartmann, Maria Pia Cosma, Yan Qin, Guo-Liang Xu, Runsheng Chen, Giacomo Volpe, Liang Chen, Jacob H. Hanna and Miguel A. Esteban (2020). "β-Catenin safeguards the ground state of mouse pluripotency by strengthening the robustness of the transcriptional apparatus."Science Advances6(eaba1593): 1-16.

    8. Jiangping He, Xiuling Fu, Meng Zhang, Fangfang He,Wenjuan Li, Mazid Md. Abdul, Jianguo Zhou, Li Sun, Chen Chang, Yuhao Li, He Liu, Kaixin Wu, Isaac A. Babarinde, Qiang Zhuang, Yuin-Han Loh, Jiekai Chen, Miguel A. Esteban and Andrew P. Hutchins (2019). "Transposable elements are regulated by context-specific patterns of chromatin marks in mouse embryonic stem cells."Nature Communications10(1): 34.

    9. Lulu Wang, Xueting Xu, Che Jiang, Gang Ma, Yinghua Huang, Hui Zhang, Yiwei Lai, Ming Wang, Tanveer Ahmed, Runxia Lin, Wenjing Guo, Zhiwei Luo,Wenjuan Li, Meng Zhang, Carl Ward, Minxian Qian, Baohua Liu, Miguel A. Esteban and Baoming Qin (2019). "mTORC1‐PGC1 axis regulates mitochondrial remodeling during reprogramming."The FEBS Journal287(1):108-121.

    10. Mazid Md Abdul, David P. Ibanez, Ping Zhao, Hao Liu, Xiaofen Zhong, Yingying Li, Meng Zhang,Wenjuan Li, Yunpan Li, Carl Ward, Shuhan Chen, Dongye Wang, Baoming Qin, Miguel A. Esteban, Xiwei Wang, Wenxia Fan, Zhiwei Luo (2019). "Generation of an induced pluripotent stem cell line (GIBHi003-A) from a Parkinson’s disease patient with mutant PINK1 (p. I368N)."Stem Cell Research41:101607.

    11. Meng Zhang, David P. Ibanez, Wenxia Fan, Hao Liu, Xiaofen Zhong, Xiwei Wang, Yingying Li, Mazid Md.Abdul,Wenjuan Li, Yunpan Li, Carl Ward, Shuhan Chen, Dongye Wang, Baoming Qin, Miguel A. Esteban, Ping Zhao, Zhiwei Luo (2019). "Generation of a PARK2 homozygous knockout induced pluripotent stem cell line (GIBHi002-A-1) with two common isoforms abolished."Stem Cell Research41:101602.

    12. Li Li, Quanjun Zhang, Huaqiang Yang, Qingjian Zou, Chengdan Lai, Fei Jiang, Ping Zhao, Zhiwei Luo, Jiayin Yang, Qian Chen, Yan Wang, Philip N. Newsome, Jon Frampton, Patrick H. Maxwell,Wenjuan Li, Shuhan Chen, Dongye Wang, Tak-Shing Siu, Sidney Tam, Hung-Fat Tse, Baoming Qin, Xichen Bao, Miguel A. Esteban and Liangxue Lai (2017). "Fumarylacetoacetate Hydrolase Knock-out Rabbit Model for Hereditary Tyrosinemia Type 1."J Biol Chem292(11): 4755-4763.

    13. Yan Xu, Meng Zhang,Wenjuan Li, Xihua Zhu, Xichen Bao, Baoming Qin, Andrew P. Hutchins and Miguel A. Esteban (2016). "Transcriptional Control of Somatic Cell Reprogramming."Trends Cell Biology26(4): 272-288.

    14. Longqi Liu, Yan Xu, Minghui He, Meng Zhang, Fenggong Cui, Leina Lu, Mingze Yao, Weihua Tian, Christina Benda, Qiang Zhuang, Zhijian Huang,Wenjuan Li, Xiangchun Li, Ping Zhao, Wenxia Fan, Zhiwei Luo, Yuan Li, Yasong Wu, Andrew P. Hutchins, Dongye Wang, Hung-Fat Tse, Axel Schambach, Jon Frampton, Baoming Qin, Xichen Bao, Hongjie Yao, Biliang Zhang, Hao Sun, Duanqing Pei, Huating Wang, Jun Wang and Miguel A. Esteban (2014). "Transcriptional pause release is a rate-limiting step for somatic cell reprogramming."Cell Stem Cell15(5): 574-588.

    15. 作為共同發明人之一申請國內發明專利三項，專利號ZL201610064508.7（已授權）、202011256758.3、？202211317527.8。

    16. 作為共同發明人之一申請國際PCT專利兩項，專利號：PCT/CN2020/128091、PCT/CN2022/081499。

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